Fluoride in Deciduous Teeth from an Anti-caries Clinical Study

Abstract

The fluoride content of both sound and white-spot enamel was determined in deciduous teeth collected from an anti-caries clinical trial which compared a 0.243% NaF dentifrice, a 0.4% SnF2 dentifrice, and a placebo. A microdrill enamel biopsy technique was developed for the analysis of white spots. No correlations were found between caries increment scores and the fluoride content of sound enamel. The enamel in white spots from users of the 0.243% NaF dentifrice had a mean fluoride content higher than that from users of the 0.4% SnF2 dentifrice. There was a negative correlation between fluoride found in white-spot enamel and caries increment scores. It is hypothesized that fluoride affects the caries rate by its control over the rate of remineralization in previously demineralized areas.

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References

Armstrong, W.D. and Brekhus, P.J. (1938): Possible Relationship Between the Fluorine Content of Enamel and Resistance to Dental Caries, J Dent Res 17:393-399.

Armstrong, W.D. and Singer, L. (1963): Fluoride Contents of Enamel of Sound and Carious Human Teeth: A Reinvestigation, J Dent Res 42:133-136.

Beiswanger, B.B. ; Gish, C.W. ; and Mallatt, M.E. (1981): A Three-Year Study of the Effect of a Sodium Fluoride-Silica Abrasive Dentifrice on Dental Caries, Pharmacol Ther Dent 6:9-16.

Depaola, P.R. ; Brudevold, F. ; Aasenden, R. ; Moreno, E.C. ; Englander, H. ; Bakhos, Y. ; Brookstein, F. ; and Warram, J. (1975): A Pilot Study of the Relationship Between Caries Experience and Surface Enamel Fluoride in Man, Arch Oral Biol 20:859-864.

Ehudin, H.E. and Soni, N.N. (1977): Fluoride Uptake by Human Enamel from Two Methods of Topical Application, J Dent Child 44:62-65.

Englander, H.R. and Mellberg, J.R. (1976): Failure to Demonstrate an Association between Enamel Fluoride Concentration and Dental Caries in the Deciduous Dentition , J Dent Res 55:707.

Fejerskov, 0.; Thylstrup, A. ; and Larsen, M.J. (1981): Rational Use of Fluoride in Caries Prevention, Acta Odontol Scand 3:241-249.

Johansen, E. (1965): Comparison of the Ultrastructure and Chemical Composition of Sound and Carious Enamel from Human Permanent Teeth. In: Tooth Enamel, M.V. Stack and R.W. Fearnhead , Eds., Bristol : John Wright & Sons, Ltd., p. 180.

Mellberg, J.R. ; Hefferren, J.J. ; Nicholson, C.R. ; Zim-Merman, M. ; and Rubin, M. (1976): A New Abrasive Applicator for Human Enamel Biopsy Procedures, J Dent Res 55: 964-969.

10.

Mobley, M.J. (1981): Fluoride Uptake from in situ Brushing with a SnF2 and a NaF Dentifrice, J Dent Res 60:1943-1948.

11.

Morrey, L.W. and Nelsen, R.J. (1970): Dental Science Handbook, Washington, DC: US Government Printing Office, DHEW Publication .

12.

Munksgaard, E.D. and Bruun, C. (1973): Determination of Fluoride in Superficial Enamel Biopsies from Human Teeth by Means of Gas Chromatography, Arch Oral Biol 18:735-744.

13.

Patel, P.R. and Brown, W.E. (1975): Thermodynamic Solubility Product of Human Tooth Enamel, J Dent Res 54:728-736.

14.

Richards, A. ; Larsen, M.J. ; Fejerskov, 0. ; and Thylstrup, A. (1977): Fluoride Content of Buccal Surface Enamel and its Relation to Dental Caries in Children, Arch Oral Biol 22:425-428.

15.

Schamschula, R.G. ; Agus, H. ; Charlten, G. ; Duppen-Thaler, J.L. ; and Un, P. (1979): Associations between Fluoride Concentration in Successive Layers of Human Enamel and Individual Dental Caries Experience , Arch Oral Biol 24:847-852.

16.

Shern, R.J. ; Driscoll, W.J. ; and Korts, D.C. (1977): Enamel Biopsy Results of Children Receiving Fluoride Tablets, JADA 95:310-314.

17.

Weatherell, J.A. ; Deutsch, D. ; Robinson, C. ; and Halls-Worth, A.S. (1977): Assimilation of Fluoride by Enamel Throughout the Life of the Tooth, Caries Res 11 (Suppl. 1): 85-115.

18.

Zacherl, W.A. (1981): A Three-Year Clinical Caries Evaluation of the Effect of a Sodium Fluoride-Silica Abrasive Dentifrice, Pharmacol Ther Dent 6:1-7.