Distortions in radiographic images caused by changes in shape and position of the film relative to the x-ray beam can result in registration artifacts which interfere with interpretation of subtracted images.
A warping transformation is described which maps known points of reference in one image into homologous points in another. The corrected image pair can then be superimposed and subtracted with significantly-reduced differences in registration to facilitate the detection of localized changes of diagnostic interest.
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