Intradental nerve activity from canine teeth of anesthetized cats was recorded during the application of different metal ion solutions in a dentinal cavity. The application of Ag2+, Ca2+, Cd2+, Cr3+, Hg 2+, Mg2+, Mn2+, Ni2+, Pb2+, Pd2+, Sn2+, and Zn2+ reduced the nerve activity induced by NaCl 0.76 M and compound 48/80. The application of Cu2+ and Co2+ excited the intradental sensory nerves.
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