Plasma beta-endorphin was measured in patients undergoing a stressful procedure, the removal of impacted third molars. In patients reporting little pain, endorphin levels increased significantly during surgery, whereas patients reporting pain and anxiety showed little increase in endorphin levels.
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References
1.
Rogers, E. and Vilkin, B.: Diurnal Variation in Sensory and Pain Thresholds Correlated with Mood States , J Clin Psychiatry39:431-433, 1978.
2.
Dent, R.: Diurnal Rhythm of Plasma Immunoreactive Beta-Endorphin and its Relationship to Sleep Stages and Plasma Rhythms of Cortisol and Prolactin, J Clin Endocrinol Metab52:942-947, 1981.
3.
Glynn, C. and Lloyd, J.: The Diurnal Variation in the Perception of Pain, Proc R Soc Med69:369-372, 1976.
4.
Gjessing, J. and Tomlin, P.: Patterns of Post-Operative Pain, Anaesthesia43:624, 1979.
5.
Denko, C.: Beta-Endorphin Levels Lower in Arthritis Patients, JAMA246:203, 1981.
6.
Rossier, J.: Foot-shock Induced Stress Increases β-Endorphin Levels in Blood But Not Brain, Nature270:618-620, 1977.
7.
Willer, J.; Dehen, H.; and Cambier, J.: Stress-induced Analgesia in Humans: Endogenous Opiates and Naloxone-Reversible Depression of Pain Reflexes, Science212 :689-691, 1981.
8.
Thomas, T.; Fletcher, J.; and Hill, R.: Influence of Medication, Pain and Progress in Labour on Plasma B-EP-LI , Br J Anaesth54:401-408, 1981.
9.
Steinbrook, R.; Carr, D.; and Datta, S.: Dissociation of Plasma and CSF B-End-LI Levels During Pregnancy and Parturition, Anesth Analg61:893-897, 1982.
10.
Dubois, M.; Pickar, D.; and Cohen, M.: Surgical Stress in Humans is Accompanied by an Increase in Plasma B-End-LI , Life Sci29:1249-1254, 1981 .
11.
Dubois, M.; Pickar, D.; and Cohen, M.: Effect of Fentanyl on the Response of Plasma Beta-Endorphin Immunoreactivity to Surgery, Anesthesiology57:468-472, 1982.
12.
Cohen, M.; Pickar, D.; Dubois, M.; and Bunney, W.: Stress Induced Plasma Endorphin Immunoreactivity May Predict Post-Operative Morphine Usage, Psychiatry Reg6:7-12, 1982.
13.
Kraynack, B. and Gintautas, J.: Naloxone: Analeptic Action Unrelated to Opiate Receptor Antagonism?, Anesthesiology56:251-253, 1982.
14.
Berkowitz, B.; Ngai, S.; and Finck, 0.: Nitrous Oxide Analgesia: Resemblance to Opiate Action , Science194 :967-969, 1976.
15.
Finck, 0.; Ngai, S.; and Berkowitz, B.: Antagonism of General Anesthesia by Naloxone in the Rat, Anesthesiology46:241-244, 1977.
16.
Gracely, R.: Psychophysical Assessment of Human Pain. In: Advances in Pain Research and Therapy, Vol. 3, Bonica, J., Ed., New York: Raven Press , 1979, pp. 805-821.
17.
Dionne, R.; Sisk, A.; Fox, P.; Wirdzek, P.; Gracely, R.; and Dubner, R.: Suppression of Post-operative Pain by Pre-operative Administration of Flurbiprofen in Comparison to Acetaminophen and Oxycodone Plus Acetaminophen , Curr Ther Res34:15-29, 1983.
18.
Goldstein, D.; Dionne, R.; Sweet , J.; Gracely, R.; Brewer, B.; Gregg, R.; and Keiser, H.: Circulating Plasma Catecholamine, Cortisol, Lipid and Psychological Responses to a Real-Life Stress (Third Molar Extraction): Effects of Diazepam Sedation and of Inclusion of Epinephrine with the Local Anesthetic, Psychosomatic Medicine44 :259-272, 1982.
19.
Sapun, D.; Farah, J.; and Mueller, G.: Evidence that a Serotonergic Mechanism Stimulates the Secretion of Pituitary B-Endorphin-like Immunoreactivity in the Rat, Endocrinology109:421-426, 1982.
20.
Hunter, W. and Greenwood, F.: Preparation of Iodine-131 Labeled Human Growth Hormone of High Specific Activity , Nature194:495-498, 1962.
