Glucose permeation from blood to saliva appeared to follow the para cellular pathway in rat submandibular and sublingual glands, and the permeability was much higher in the sublingual than in the submandibular gland. The duct system re-absorbed glucose in the submandibular but not the sublingual gland. The glucose concentration in sublingual saliva was inversely related to the flow rate.
Get full access to this article
View all access options for this article.
References
1.
Mandel, I.D. ; Hampar, B.; Thompson , R.H., Jr.; and Ellison , S.A.: The Carbohydrates of Human Parotid Saliva, Arch Oral Biol3 :278-282, 1961.
2.
Langley, L.L. ; Hanson, R.W.; Grimes , O.R., Jr. ; Cock-Rell , D.F., Jr.; and Knight, L.A.: Secretion of Glucose-C14 by Dog Parotid Gland, Arch Oral Biol8:127-133, 1963.
3.
Martin, K. and Burgen, A.S.V.: Changes in the Permeability of the Salivary Gland Caused by Sympathetic Stimulation and by Catecholamines, J Gen Physiol46:225-243, 1962.
4.
Wright, E.M. and Pietras, R.J.: Routes of Nonelectrolyte Permeation across Epithelial Membranes, J Membr Biol17:293-312, 1974.
5.
Yoshida, Y.; Sprecher, R.L.; Schneyer, C.A.; and Schneyer, L.H.: Role of β-receptors in Sympathetic Regulation of Electrolytes in Rat Submaxillary Saliva, Proc Soc Exp Biol Med126:912-916, 1967.
6.
Matthews, R.W. : The Effects of Autonomic Stimulation upon the Rat Submandibular Gland, Arch Oral Biol19 :989-994, 1974.
7.
Sprecher, R.L. ; Yoshida, Y.; and Schneyer, L.H.: Partial Isolation and Perfusion of Rat Submaxillary Gland, Proc Soc Exp Biol Med125:1227-1229, 1967.
8.
Takai, N.; Yoshida, Y.; and Kakudo, Y.: Technique for Collection of Saliva from the Three Major Salivary Glands of Individual Rats, J Osaka Dent Univ16:17-23, 1982.
9.
Trinder, P.: Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor, Ann Clin Biochem6:24-27, 1969.
10.
Burgen, A.S.V. : The Secretion of Non-electrolytes in the Parotid Saliva, J Cell Comp Physiol48:113-138, 1956.
11.
Schultz, S.G. and Zalusky, R.: Ion Transport in Isolated Rabbit Ileum. 11. The Interaction between Active Sodium and Active Sugar Transport , J Gen Physiol47:1043-1059, 1964 .
12.
Pearce, R.G. : The Appearance of Sugar in the Secretions of the Digestive Tract Following the Administration of Phlorhizin, Am J Physiol40:418-425, 1916.
13.
Dawes, C.; Dowse, C.M.; and Knull, H.R.: Stop-flow Effects on Human Salivary Composition and Hydrostatic Pressures , Arch Oral Biol25 :251-256, 1980.
14.
Schwartz, A. and Moore, C.A.: Highly Active Na+, K+-ATPase in Rat Submaxillary Gland Bearing on Salivary Secretion, Am J Physiol214:1163-1167, 1968.
15.
Bundgaard, M.; Mller, M.; and Poulsen, J.H.: Localization of Sodium Pump Sites in Cat Salivary Glands, J Physiol (Lond)273:339-353, 1977.
16.
Herreros, B. ; Barbosa, E.; Ojeda , J.L.; and Bosque, P.G.: Effect of Diethylstilbestrol on Glucose Absorption by Rat Small Intestine in vitro, Experientia26:518, 1970.
17.
Jansen, J.W.C.M. ; Schreurs, V.V.A.M.; Swarts, H.G.P.; Fleuren-Jakobs , A.M.M.; De Pont, J.J.H.H.M.; and Bonting, S.L.: Role of Calcium in Exocrine Pancreatic Secretion. VI. Characteristics of the Paracellular Pathway for Divalent Cations, Biochim Biophys Acta599:315-323, 1980.
18.
Slegers, J.F.G. ; Moons, W.M.; Idzerda , P.P.; and Stadhouders , A.M.: The Contribution of a Chloride Shunt to the Transmucosal Potential of the Rabbit Submaxillary Duct, J Membr Biol25:213-216, 1975.
19.
Van Os, C.H.; De Jong, M.D.; and Slegers, J.F.G.: Dimensions of Polar Pathways through Rabbit Gallbladder Epithelium. The Effect of Phloretin on Nonelectrolyte Permeability , J Membr Biol15:363-382, 1974.
20.
Garrett, J.R. : Permeability of Salivary Glands to Macromolecules . In: Advances in Physiological Sciences, Vol. 28, Zelles, T., Ed., Budapest: Pergamon Press and Publishing House of the Hungarian Academy of Sciences, 1981, pp. 109-117.
21.
Schwartz, I.L. ; Thaysen, J.H.; and Dole, V.P.: Urea Excretion in Human Sweat as a Tracer for Movement of Water within the Secreting Gland , J Exp Med97:429-437, 1953.
22.
Mangos, J.A. ; Maragos, N.; and McSherry, N.R.: Micropuncture and Microperfusion Study of Glucose Excretion in Rat Parotid Saliva, Am J Physiol224:1260-1264, 1973.
