An Ag-Cu-Ge alloy and an Au-Ge alloy were evaluated for their hemolytic effect on rabbit blood, cytotoxicity to α-L fibrosarcoma cells, and allergenic effect on guinea pigs. Neither alloy evoked a significant hemolytic response; cytotoxicity, and that of pure germanium, was no greater than that of ZOE cement; and, on the basis of the guinea pig response, the potential human allergenic response was considered to be Grade I (weak) and Grade II (mild), respectively.
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References
1.
YOUDELIS, W.V. and YOUDELIS, R.A.: Silver-Copper-Germanium Alloys, J Can Dent Assoc 47:101-106, 1981. 2. Association Reports: Council on Dental Materials and Devices, JADA 99:697-698, 1979.
2.
American National Standards Institute/American Dental AssociationDocument No. 41 for Recommended Standard Practices for Biological Evaluation of Dental Materials, Chicago, Illinois: American Dental Association, 1979, pp. 1-86.
3.
Commission on Dental Materials, Instruments, Equipment, and Therapeutics and the Commission on Dental Research, FDI/ ADA , International Conference: Standardization of Methods for Evaluation of Tissue Reactions to Dental Restorative Procedures, Materials and Therapeutics, Int Dent J20 :472-532, 1970.
4.
Stanford, J.W. : Recommended Standard Practices for Biological Evaluation of Dental Materials: Federation Dentaire Internationale, Commission on Dental Materials, Instruments, Equipment, and Therapeutics, Int Dent J30:140-188, 1980.
Council on Dental Materials and Devices: Certification Programs for Dental Materials and Devices, JADA96 :124-134, 1978.
7.
Sims, T.; Clagett, J.A.; and Page, R.C.: Effects of Cell Concentration and Exogenous Prostaglandin on the Interaction and Responsiveness of Human Peripheral Blood Leukocytes, Clin Immunol Immunopathol12:150-161, 1979.
8.
Spangberg, L. : Kinetic and Quantitative Evaluation of Material Cytotoxicity in vitro, Oral Surg35:389-4001973.
9.
Townsend, J.D. ; Hamilton, A.I.; and Sbordone , L.: Biologic Evaluation of an Amalgam Containing Indium and Two Germanium-containing Alloys for Cast Prostheses, AADR Progr & Abst62: No. 472, 1983.
10.
Magnusson, B. and Kligman, A.M.: The Identification of Contact Allergens by Animal Assay. The Guinea Pig Maximization Test, J Invest Dermatol52:268-276, 1969.
11.
Black, J.: Biological Performance of Materials. In: Biomedical Engineering and Instrumentation Series, Vol. 8, Plonsky, R. and Katz, J.L., Eds., New York and Basel: Marcel Dekker, Inc., 1981, pp. 195-200.
12.
Dhal, B.L. and Orstavik, J.: Cytotoxicity of Temporary Crown and Bridge Materials, J Oral Rehabil3:341-347, 1976.
13.
Browne, R.M. and Tyas, M.J.: Biological Testing of Dental Restorative Materials in vitro - A Review, J Oral Rehabil6 : 365-374, 1979.
14.
Hensten-Pettersen, A. and Helgeland, K.: Evaluation of Biologic Effects of Dental Materials Using Four Different Cell Culture Techniques, Scand J Dent Res85:291-296, 1977.
