Electron microscope radio-autography was used in an attempt to identify any relationship between the location and degree of differentiation of progenitor cells in the periodontal ligament (PDL). Ligament fibroblasts were classified on the basis of their nuclear/ cytoplasmic ratio and their distance to the closest blood vessel measured. It was determined that an undifferentiated paravascular progenitor cell population exists, and that the PDL also contains progenitor cells showing a range of cytodifferentiation.
Get full access to this article
View all access options for this article.
References
1.
Gould, T.R.L. ; Melcher, A.H.; and Brunette , D.M.: Location of Progenitor Cells in Periodontal Ligament of Mouse Molar Stimulated by Wounding , Anat Rec188:133-141, 1977.
2.
Gould, T.R.L. ; Melcher, A.H.; and Brunette , D.M.: Migration and Division of Progenitor Cell Populations in Periodontal Ligament after Wounding, J Periodont Res15:20-42, 1980.
3.
McCulloch, C.A.G. and Melcher, A.H.: Variations in Cell Density and Labeling Index in Mouse Periodontal Ligament, IADR Progr & Abst60:No. 563, 1981.
4.
Melcher, A.H. : The Connective Tissues of the Periodontium . In: Biology of the Periodontium, Melcher, A.H. and Bowen, W.H., Eds., New York: Academic Press, 1969, pp. 167-343.
5.
Ham, A.W.: Histology, 7th ed., Toronto: J.B. Lippincott Co., 1974 , p. 222.
6.
Kopriwa, B.M. : A Reliable, Standardized Method for Ultrastructural Electron Microscope Radioautography, Histochemie37:1-17,1973.
7.
Leblond, C.P. and Cheng, H.: Identification of Stem Cells in the Small Intestine of the Mouse. In: Stem Cells in Renewing Cell Populations, Cairnie, A.B., Lala, P.K., and Osmond, D.G., Eds., New York: Academic Press, 1976, pp. 7-31.
8.
Scott, B.L. : Thymidine H3 Electron Microscope Radioautography of Osteogenic Cells in the Fetal Rat, J Cell Biol35: 115-126, 1967.
9.
Roberts, W.E. and Jee, W.S.S.: Cell Kinetics of Orthodontically Stimulated and Non-stimulated Periodontal Ligament in the Rat, Arch Oral Biol19:17-21, 1974.
10.
Brunette, D.M. ; Melcher, A.H.; and Moe , H.K.: Culture and Origin of Epithelium-like and Fibroblast-like Cells from Porcine Periodontal Ligament Explants and Cell Suspensions, Arch Oral Biol21 :393-400, 1976.
