Effects of androgens on the activity of androgen-metabolizing enzymes have been investigated in the murine submaxillary gland. 5α-reductase activity is androgen-dependent, and 17β-hydroxysteroid dehydrogenase activity is androgen-resistant. The level and androgen-responsiveness of 5α-reductase in the murine submaxillary gland are not imprinted during the neonatal period by testicular androgens. Circulating androgen may have a cumulative effect on androgen response of 5α-reductase.
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