Fairly high collagenase activity was initially demonstrated in human whole saliva, and the activity from patients with periodontal diseases was statistically higher than that from healthy subjects. Based on some characteristic properties, the collagenase in whole saliva appeared to be of tissue, rather than bacterial, origin.
Fullmer, H.M. and Gibson, W.,; Collagenolytic Activity in Gingivae of Man , Nature209:728, 1966.
3.
Geiger, S., and Harper E.: Human Gingival Collagenase in Periodontal Disease: The Release of Collagenase and the Breakdown of Endogenous Collagen in Gingival Explants, J Dent Res59:11, 1980.
4.
Uitto, V.-J. ; Turto. H.; and Saxen, L.: Extraction of Collagenase from Human Gingiva , J Periodont Res13:207, 1978.
5.
Iijima, K.; Kishi, J.; Fuyamara, H.; Nagatsu, T.; and Hayakawa, T.: Dental Sac Collagenase: Demonstration and Initial Characterization , J Dent Res57:724, 1978.
6.
Iijima, K.; Kishi, J.; and Hayakawa, T.: Purification and Characterization of Bovine Dental Sac Collagenase , J Biochem89:1101, 1981.
7.
Kishi, J.; Hjima, K.; and Hayakawa T.: Dental Pulp Collagenase: Initial Demonstration and Characterization, Biochem Biophys Res Commun86:27. 1979.
8.
Golub, L.M.; Siegel, K.; Ramamurthy, N.S.: and MAN-DEL, I.D.: Some Characteristics of Collagenase Activity in Gingival Crevicular Fluid and Its Relationship to Gingival Diseases in Humans , J Dent Res55:1049. 1976.
9.
Golub, L.M.; Kaplan, R.; Mulvihill, J.E.; and Ramamurthy, N.S. : Collagenolytic Activity of Crevicular Fluid and of Adjacent Gingival Tissue, J Dent Res58:2132. 1979.
10.
Loë, H. and Silness, J.: Periodontal Disease in Pregnancy. I, Prevalence and Severity, Acta Odontol Scand21:533, 1963.
11.
Schei, O.; Waerhaug, J.; Lovdal, A.; and Arno, A.: Alveolar Bone Loss as Related to Oral Hygiene and Age, J Periodontol30:7, 1959.
12.
Weber, K. and Osborn, M.: The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis, J Biol Chem244:4406, 1969 .
13.
Terato, K.; Nagai, Y.; Kawanishi, K.; and Yamamo-To, S.: A Rapid Assay Method of Collagenase Activity Using 14C-Labeled Soluble Collagen as Substrate, Biochim Biophys Acta445:753, 1976,
14.
Hartree, E.F. : Determination of Protein: A Modification of
15.
the Lowry Method That Gives a Linear Photometric Response, Anal Biochem48:422, 1972.
16.
Wunsch, E. and Heidrich, H.-G.: Zur Quantitativen Bestimmung der Kollagenase, Hoppe Seyler's Z Physiol Chem333: 149,1963.
17.
Iijima, K.; Takei, T.; Hino, M.; and Hayakawa, T.: A New Fluorescence Assay for Dipeptidylpeptidase IV Using Tripeptide L-Prolyl-L-Prolyl-L-Alanine as Substrate, J Biochem Biophys Meth3:89, 1980.
18.
Kunitz, M.: Crystalline Soybean Trypsin Inhibitor (II. General Properties), J Gen Physiol30:291, 1947.
19.
Sacher, L.A. ; Winter, K.K.; Sicher , N.; and Frankel, S.: Photometric Method for Estimation of Elastase Activity, Proc Soc Exp Biol Med90:323, 1955.
20.
Schwabe, C. : A Fluorescent Assay for Proteolytic Enzymes , Anal Biochem53:484, 1973.
21.
Soderling, E. and Paunio, K.U.: Conditions of Production and Properties of the Collagenolytic Enzymes by Two Bacillus Strains from Dental Plaque, J Periodont Res16:513, 1981.
22.
Attström, R. and Egelberg, J.: Emigration of Blood Neutrophils and Monocytes into the Gingival Crevices, J Periodont Res5:48, 1970.
23.
Watanabe, T. ; Ohata, N.; Morishita , M.; and Iwamo-To, Y.: Correlation Between the Protease Activities and the Number of Epithelial Cells in Human Saliva, J Dent Res60: 1039,1981.
24.
Burleigh, M.C.: Degradation of Collagen by Non-Specific Proteinases. In: Proteinases in Mammalian Cells and Tissues, Amsterdam: North-Holland Publishing Company, 1977, pp. 285-309.