An endo-1,3-α-D-glucanase was evaluated for its dental caries-preventive efficacy in male Syrian hamsters. The enzyme significantly reduced both total caries and carious area scores.
Get full access to this article
View all access options for this article.
References
1.
Fitzgerald, R.J. and Jordan, H.V.: Polysaccharide-Producing Bacteria and Caries. In: Art and Science of Dental Caries Research, Harris, R.S. , Ed., New York, NY: Academic Press, Inc. , 1968, pp. 79-86.
2.
Newbrun, E.: Polysaccharide Synthesis in Plaque. In: Proceedings : Microbial Aspects of Dental Caries, Vol. 3, Special Supplement , Stiles, H.M., Loesche, W.J., and O'Brien, T.C., Eds., Washington, DC: Microbiological Abstracts, Information Retrieval, Inc., 1976, pp. 649-664.
3.
Guggenheim, B.: Enzymatic Hydrolysis and Structure of Water-Insoluble Glucan Produced by Glucosyltransferases from a Strain of Streptococcus mutans , Helv Odontol Acta14 :89-108 (Suppl. V), 1970.
4.
Colson, P.; Jarrell, H.C.; Lamberts, B.L.; and Smith, I.C.P.: Determination by Carbon-13 Nuclear Magnetic Resonance Spectroscopy of the Composition of Glucans Synthesized by Enzymes of the Cariogenic Organism Streptococcus mutans, Carbohydr Res86:265-272, 1979.
5.
Tanzer, J.M. : Essential Dependence of Smooth Surface Caries on and Augmentation of Fissure Caries by Sucrose and Streptococcus mutans Infection, Infect Immun25:526-531, 1979.
6.
Shklair, I.L. and Gaugler, R.W.: Glucan Synthesis by the Oral Bacterium Streptococcus mutans from Caries-Active and Caries-Free Naval Recruits , Arch Oral Biol26:683-686, 1981.
7.
Wenham, D.G. ; Davies, R.M.; and Cole, J.A.: Insoluble Glucan Synthesis by Mutansucrase as a Determinant of the Cariogenicity of Streptococcus mutans, J Gen Microbiol127: 407415, 1981 .
8.
DE Stoppelaar, J.D.; Konig, K.G.; Plasschaert , A.J.M.; and Van der Hoeven, J.S.: Decreased Cariogenicity of a Mutant of Streptococcus mutans, Arch Oral Biol16:971-975, 1971.
9.
Simonson, L.G. ; Lamberts, B.L.; and Reiher, D.A.: Production of α-1,3-Glucanase by a New Bacterial Source (Pseudomonas), Microbios Lett14:107-112, 1980.
10.
Lamberts, B.L. ; Simonson, L.G.; Pederson , E.D.; and Gaugler, R.W.: A New Method for the Detection and Assay of α-1,3-Glucanases, Anal Biochem117:320-326, 1981.
11.
Simonson, L.G. ; Gaugler, R.W.; Lamberts , B.L.; and Reiher, D.A.: Purification and Properties of Endo-1,3-α-D-Glucanase from Pseudomonas, Biochim Biophys Acta715: 189-195, 1982.
12.
Simonson, L.G. ; Jackola, D.; Lamberts , B.L.; and Leonard, E.P.: Effects of Two Dextranase Preparations on Dental Caries and Alveolar Bone Loss in Hamsters , Pharmacol Therap Dent4:47-51, 1979.
13.
Guggenheim, B. and Haller, R.: Purification and Properties of an α-1,3-Glucanohydrolase from Trichoderma harzianum, J Dent Res51:394-402, 1972.
14.
Keyes, P.H. : A Method of Recording and Scoring Gross Carious Lesions in the Molar Teeth of Syrian Hamsters, J Dent Res23:439-444, 1944.
15.
Guggenheim, B.; Regolati, B.; and Muhlemann, H.R.: Caries and Plaque Inhibition by Mutanase in Rats, Caries Res6:289-297, 1972.
16.
Guggenheim, B.; Regolati, B.; Schmid , R.; and Müh-Lemann , H.R.: Effects of the Topical Application of Mutanase on Rat Caries, Caries Res14:128-135, 1980.
17.
Kelstrup, J. ; Funder-Nielsen, T.D.; and Moller, E.N.: Enzymatic Reduction of the Colonization of Streptococcus mutans in Human Dental Plaque , Acta Odontol Scand31 :249-253, 1973.
18.
Kelstrup, J. ; Holm-Pederson, P.; and Poulsen, S.: Reduction of the Formation of Dental Plaque and Gingivitis in Humans by Crude Mutanase , Scand J Dent Res86:93-102, 1978.
19.
Takehara, T. and Inoue, M.: Inhibitory Effects of Endo-α-1, 3-Glucanase on Glucan Film Formation and Glucan Synthesis by the Glucosyltransferase of the Oral Bacterium Streptococcus mutans, Arch Oral Biol26:217-222, 1981.
20.
Simonson, L. ; Lamberts, B.; Reiher , D.; and Walter, R.: Prevention of Experimental Dental Caries in Hamsters by a Bacterial a-1, 3-Glucanase, IADR Progr & Abst60:No. 558, 1981.
21.
Hojo, S.; Higuchi, M.; and Araya, S.: Glucan Inhibition of Diffusion in Plaque, JDent Res55:169, 1976.