Clarified and dialyzed mixed saliva-water rinses, obtained from patients receiving radiation treatment of the major salivary glands, exhibited quantitative reductions in total protein content and qualitative changes in protein composition. Radiation or post-radiation saliva preparations supported enhanced growth of Streptococcus mutans, but reduced growth of Streptococcus sanguis relative to growth on pretreatment saliva.
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References
1.
Shannon, I.L. ; Starcke, E.N.; and Westcott , W.B.: Effect of Radiotherapy on Whole Saliva Flow, J Dent Res56: 693, 1977.
2.
Brown, L.R.; Dreizen, S.; Rider, L.J.; and Johnston, D.A.: The Effect of Radiation-Induced Xerostomia on Saliva and Serum Lysozyme and Immunoglobulin Levels, Oral Surg41:83-92, 1976.
3.
Dreizen, S.; Brown, L.R.; Handler, S.; and Levy, B.M.: Radiation Induced Xerostomia in Cancer Patients. Effect on Salivary and Serum Electrolytes, Cancer38:273-278, 1976.
4.
Brown, L.R.; Dreizen, S.; Daly, T.E.; Drane, J.B.; Handler, S.; Riggan, L.J.; and Johnston, D.A.: Interrelations of Oral Microorganisms, Immunoglobulins, and Dental Caries Following Radiotherapy, J Dent Res57:882-893, 1978.
5.
Dreizen, S.; Brown, L.R.; Daly, T.E.; and Drane, J.B.: Prevention of Xerostomia-related Dental Caries in Irradiated Cancer Patients , JDent Res56:99-104, 1977.
6.
Llory, H.; Dammron, A.; Gioanni, M.; and Frank, R.J.: Some Population Changes in Oral Anaerobic Microorganisms, Streptococcus mutans and Yeasts Following Irradiation of the Salivary Glands, Caries Res6:298-311, 1972.
7.
Brown, L.R.; Dreizen, S.; Handler, S.; and Johnston, D.A.: Effect of Radiation-induced Xerostomia on Human Oral Microflora, Dent Res54:740-750, 1975.
8.
Dreizen, S. and Brown, L.R.: Xerostomia and Dental Caries. In: Proceedings: Microbial Aspects of Dental Caries, Vol. 1, Stiles, Loesche , and O'Brien, Eds., Sp. Suppl., Microbiology Abstracts, 1976, pp. 263-273.
9.
Brown, L.R.; Dreizen, S.; and Handler, S.: Effects of Selected Caries Preventive Regimens on Microbial Changes Following Irradiation-Induced Xerostomia in Cancer Patients. In: Proceedings: Microbial Aspects of Dental Caries, Vol. 1, Stiles, Loesche, and O'Brien, Eds., Sp. Suppl., Microbiology Abstracts, 1976, pp. 275-290.
Cowman, R.A. ; Fitzgerald, R.J.; Perrella, M.M.; and Cornell, A.H.: Human Saliva as a Nitrogen Source for Oral Streptococci, Caries Res11:1-8, 1977.
12.
Cowman, R.A. ; Schaefer, S.J.; and Fitzgerald , R.J.: Specificity of Utilization of Human Salivary Proteins for Growth by Oral Streptococci, Caries Res13:181-189, 1979.
13.
Cowman, R.A. ; Baron, S.J.; and Fitzgerald , R.J.: Utilization of Hydroxyapatite Adsorbable Salivary Proteins as Growth Substrates for Plaque-forming Oral Streptococci, J Dent Res60:1803-1808, 1981 .
14.
Cowman, R.A. ; Schaeffer, S.J.; Fitzgerald, R.J.; Rosner, D.; Shklair, I.L.; and Walter, R.G.: Differential Utilization of Proteins in Saliva from Caries-active and Caries-free Subjects as Growth Substrates by Plaque-forming Streptococci, J Dent Res58:2019-2027, 1979.
15.
Cowman, R.A. ; Perrella, M.M.; and Fitzgerald , R.J.: Influence of Incubation Atmosphere on Growth and Amino Acid Requirements of Streptococcus mutans, Appl Microbiol27:86-92, 1974.
16.
Dubois, M.; Gilles, K.A.; Hamilton, J.K.; Rebers, P.A.; and Smith, F.: Colorimetric Method for the Determination of Sugars and Related Substances , Anal Chem28: 350-356,1956.
17.
Iwamoto, Y. ; Tsunemitsu, A.; and Okuda, K.: Iodide Peroxidase Activity in the Antibacterial System in Human Parotid and Submandibular Saliva, J Dent Res51:877, 1972.
18.
Rosenmund, H. and Kaczmarek, M.J.: Isolation and Characterization of Isozymes of Human Salivary and Pancreatic α-Amylase, Clin Chim Acta71:185-189, 1976.
19.
Mandel, I.D. and Wotman, S.: The Salivary Secretions in Health and Disease , Oral Sci Rev8:24-47, 1976.
20.
Sodicoff, M. ; Pratt, N.E.; Trepper, P.; Sholley, M.M.; and Hoffenberg , S.: Effects of X-Irradiation on the Resultant Inanition of Amylase Content of the Rat Parotid Gland, Arch Oral Biol22:261-267, 1977.
21.
Thomas, E.L. : Myeloperoxidase, Hydrogen Peroxide, Chloride Antimicrobial System: Nitrogen-Chloride Derivatives of Bacterial Components in Bactericidal Action against Escherichia coli, Infect Immun23:522-531, 1979.
22.
Hager, L.P. ; Morris, D.R.; Brown, S.F.; and Eberwein , H.: Chloroperoxidase. II. Utilization of Halogen Anions, J Biol Chem241:1769-1777,1966.
23.
Cowman, R.A. and Schaefer, S.J.: Amino Acid Requirements and Human Saliva as a Nitrogen Source for Streptococcus salivarius and Streptococcus mitior , J Dent Res57:48, 1978.