The effects of 12 amphipathic compounds-such as aromatic and aliphatic carboxylic acids, amines, imines, nitrogen-substituted derivatives, and aldehydes-on multilamellar liposomes with varying charges were monitored in biological systems. The stabilization-lysis action of amphipathic compounds on liposomes was influenced by either the electrostatic repulsion or the attraction force between these compounds and liposomes.
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References
1.
Szoka, F., Jr. and Papahadjopoulos, D.: Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes), Ann Rev Biophys Bioeng9:467-508, 1980.
2.
Fujisawa, S. ; Kadoma, Y.; and Masuhara, E.: Action of Drugs, Detergents, and Monomers , J Dent Res, In press.
3.
Bangham, A.D. ; Standish, M.M.; and Watkins, J.C.: Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids, J Mol Biol13:238-252, 1965.
4.
Fujisawa, S. and Masuhara, E.: Binding of Eugenol and O-ethoxybenzoic Acid to Bovine Serum Albumin, J Dent Res60:860-864, 1981.
5.
Harford, D.J. and Smith, M.J.H.: The Effect of Sodium Salicylate on the Release of Acid Phosphates Activity from Rat Liver Lysosomes in vitro , J Pharm Pharmacol22:578-583, 1970.
6.
Riethe, P.; Schmelzle, R.; and Schwenzer, N.: Arzneimitteltherapie in der Zahn-, Mund- und Kieferheilkunde, Stuttgart : Thieme, 1980, pp. 55-56.
7.
Papahadjopoulos, D. and Weiss, L.: Amino Groups at the Surfaces of Phospholipid Vesicles, Biochim Biophys Acta183:417-426, 1969.
8.
Hardy, P.M.; Nichols, A.C.; and Rydon, H.N.: The Nature of Glutaraldehyde in Aqueous Solution, Chem Comm360: 565-566, 1969.
9.
Dingle, J.: Action of Vitamin A on the Stability of Lysosomes in vivo and in vitro, Ciba Foundation Symposium on Lysosomes, London: J. and A. Churchill, 1963, pp. 384-398.
