Phosphate deficiency imposed on weanling rats for two wk resulted in a 40% increase in alkaline phosphatase activity of incisor pulp, without a significant change in Ca2+-, Mg2+-ATPase activity. The results are consistent with a separate identity for the two enzymes, but their physiological roles remain obscure.
Get full access to this article
View all access options for this article.
References
1.
Robison, R.: The Possible Significance of Hexosephosphoric Esters in Ossification, Biochem J17:286-293, 1923.
2.
Anderson, H.C.: Calcium Accumulating Vesicles in the Intercellular Matrix of Bone. In: Hard Tissue Growth, Repair and Remineralization, Ciba Foundation Symposium 11 (new series), Amsterdam: Elsevier-Excerpta Medica, 1973, pp. 213-226.
3.
Heyden, G. and From, S.H.: A Histochemical Demonstration of ATPase Activity During Tooth Ontogeny in the Mouse, Arch Oral Biol14:1125-1132, 1969.
4.
Severson, A.R. : Histochemical Demonstration of Nucleoside Triphosphate Hydrolysis in the Mouse Dentition, Acta Histochem40:86-97, 1971.
5.
Messer, H.H. and Guo, M.K.: Lack of Relation of Pulp Ca2+-, Mg2+-ATPase to Mineralization Rate in Rat Incisor Dentine in Response to Vitamin D and Calcium Intake, Arch Oral Biol24:271-275, 1979.
6.
Messer, H.H. ; Rogers, J.; Shami, Y.; and Copp, D.H.: Ca2+-, Mg2+-activated ATPase and Alkaline Phosphatase of Developing Chick Femora, Comp Biochem Physiol51B :19-24,1975.
7.
Messer, H.H. ; Tate, G.; and Reade, P.C.: Distribution of Ca2+-, Mg2+-ATPase Activity in Bovine Dental Pulp, J Dent Res57:865, 1978.
8.
Farley, J.R. ; Ivey, J.L.; and Baylink, D.J.: Human Skeletal Alkaline Phosphatase. Kinetic Studies Including pH Dependence and Inhibition by Theophylline, J Biol Chem255:4680-4686, 1980.
9.
Kempson, S.A. and Dousa, T.P.: Phosphate Transport Across Renal Cortical Brush Border Membrane Vesicles from Rats Stabilized on a Normal, High or Low Phosphate Diet, Life Sci24:881-888, 1979.
10.
Wergedal, J.E. : Enzymes of Protein and Phosphate Catabolism in Rat Bone. I. Enzyme Properties in Normal Rats, Calcif Tissue Res3:55-66, 1969.
11.
Baylink, D. ; Wergedal, J.; and Stauffer, M.: Formation, Mineralization, and Resorption of Bone in Hypophosphatemic Rats, J Clin Invest50:2519-2530, 1971.
12.
Taussky, H.H. and Shorr, E.: A Microcolorimetric Method for the Determination of Inorganic Phosphorus, J Biol Chem202:675-685, 1953.
13.
Linhardt, K. and Walter, K.: Phosphatases. In: Methods of Enzymatic Analysis, Burgmeyer, H.J., Ed., New York: Academic Press, 1965, pp. 783-785.
14.
Guo, M.K. and Messer, H.H.: Properties of Ca2+-, Mg2+activated Adenosine Triphosphatase from Rat Incisor Pulp, Arch Oral Biol21:637-640, 1976.
15.
Lowry, O.H. ; Rosebrough, N.J.; Farr, A.L.; and Randall, R.J. : Protein Measurement with the Folin Phenol Reagent, J Biol Chem193:265-275, 1951.
16.
Bruin, W.J. ; Baylink, D.J.; and Wergedal , J.E.: Acute Inhibition of Mineralization and Stimulation of Bone Resorption Mediated by Hypophosphatemia , Endocrinology96: 394-399,1975.
17.
Cuisinier-Gleizes, P.; Thomasset, M.; Sainteny-Debove , F.; and Mathieu, H.: Phosphorus Deficiency, Parathyroid Hormone and Bone Resorption in the Growing Rat, Calcif Tissue Res20:235-249, 1976.
18.
Harrison, J.E. ; Hitchman, A.J.W.; Hasany, S.A.; McNeill, K.G.; and Tam, C.S.: Differences Between the Effects of Phosphate Deficiency and Vitamin D Deficiency on Bone Metabolism, Metabolism29:1225-1233, 1980.
19.
Gaunt, W.E. and Irving, J.T.: The Influence of Dietary Calcium and Phosphorus upon Tooth Formation, J Physiol99:18-29, 1940.
20.
Shamoo, A.R. and Bronner, F.: Vitamin D-induced Changes in the Renal Membrane ATPase System, Calcif Tissue Res17:189-194, 1975.
21.
Guo, M.K. and Messer, H.H.: A Comparison of Ca2+-, Mg2+-ATPase and Alkaline Phosphatase Activities of Rat Incisor Pulp, Calcif Tissue Res26:33-38, 1978.