The susceptibility of selected oral bacteria, including suspected periodontopathogens, to a commonly employed Chinese herbal medicine Huang-chin (HC, Scutellaria baicalensis) was tested in vitro. The minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) were determined. HC was also compared with tetracycline, alexidine, and stannous fluoride. HCdecoction, ata concentration of 2%, was bacteriostatic in eight of 11 bacteria tested, but a concentration of 3.13% or greater was required for bactericidal effect. Among the tested bacteria, Bacteroides melaninogenicus ss intermedius was the most sensitive (MIC = 1.57%, MBC = 2%); Actinomyces viscosus was the least sensitive (MIC = 6.25%, MBC 12.5%). Tetracycline, alexidine, and SnF2 were bactericidal in vitro in all bacteria tested at concentrations lower than those used clinically.
Socransky, S.S. : Microbiology of Periodontal Disease- Present Status and Future Consideration, J Periodontol48: 497-504,1977.
4.
Feng, K.Y.: The Pharmaceutic Effects of Chinese Herb- Scutellaria baicalensis (Huang-chin) . Literature review, Harbin Chinese Medicine8:37-43, 1965.
5.
Academy of Traditional Chinese Medicine: Studies on the Chemical Constituents of Traditional Drug Scutellaria baicalensis - Huang-chin, Chinese Medical Journal7:90, 1973.
6.
Jiang-su New Medical College: Dictionary of Chinese Drugs, Shanghai: Shanghai People's Publisher, 1977, p. 4146.
7.
Wang, X.K. and Lee, M.J.: The Extraction and Analysis of Antimicrobial Components of Scutellaria baicalensis , Arch Sichuan Medical College No. 4:97-98, 1959.
8.
Chen, H.C.: New Pharmacology, 10th ed., Peking: People's Health Publisher, 1974, p. 131.
9.
Liu, S.S., Ed.: Abstracts of Scientific Articles on Chinese Medicine (1820-1961), Peking: Science Publisher, 1963,p. 578.
10.
WANG, X.K. (Dept. of Pharmacology, Sichuan Medical College), Personal communication, 1981.
11.
Spolsky, V.W. ; Bhatia, H.L.; and Forsythe , A.: The Effect of an Antimicrobial Mouthwash on Dental Plaque and Gingivitis in Young Adults , J Periodontol46:685-690, 1975.
12.
Carlson, H.C. and Porter, K.: Inhibitory Effect of a Synthetic Antibiotic Mouthwash (QR-711) on Dental Plaque and Gingivitis in Young Adults , J Periodontol44:225-227, 1973.
13.
Carlson, H.C. ; Porter, K.; and Alms, T.H.: The Effect of an Alexidine Mouthwash on Dental Plaque and Gingivitis, J Periodontol48:216-218, 1977.
14.
Lobene, R.R. and Soparkar, P.M.: The Effect of an Alexidine Mouthwash on Human Plaque and Gingivitis, JADA87:848-851, 1973.
15.
Tinanoff, N. ; Brady, J.M.; and Gross, A.: The Effect of NaF and SnF2 Mouthrinses on Bacterial Colonization on Tooth Enamel: TEM and SEM Studies, Caries Res10:415-426, 1976.
16.
Tinanoff, N. ; Hock, J.; Camosci , D.; and Hellden, L.: Effect of Stannous Fluoride Mouthrinse on Dental Plaque Formation, J Clin Periodontol7:232-241, 1980.
17.
Mazza, J.E. ; Newman, M.G.; and Sims, T.N.: Clinical and Antimicrobial Effect of Stannous Fluoride on Periodontitis, J Clin Periodontol8:203-212, 1981.
Yoon, N.A. and Berry, C.W.: The Antimicrobial Effect of Fluorides (Acidulated Phosphate, Sodium and Stannous) on Actinomyces viscosus, J Dent Res58:1824-1829, 1979.
20.
Yoon, N.A. and Newman, M.G.: Antimicrobial Effect of Fluorides on Bacteroides melaninogenicus Subspecies and Bacteroides asaccharolyticus, J Clin Periodontol7:489-494, 1980.
21.
Hellden, L.; Camosci, D.; Hock, J.; and Tinanoff, N.: Clinical Study to Compare the Effect of Stannous Fluoride and Chlorhexidine Mouthrinse on Plaque Formation, J Clin Periodontol8:12-16, 1981.
22.
Goodson, J.M. ; Haffajee, A.; and Socransky, S.S.: Periodontal Therapy by Local Delivery of Tetracycline, J Clin Periodontol6:83-92, 1979.
23.
Lindhe, J.; Heijl, L.; Goodson, J.M.; and Socransky, S.S.: Local Tetracycline Delivery Using Hollow Fiber Devices in Periodontal Therapy , J Clin Periodontol6:141-149, 1979.
24.
Listgarten, M.A.; Lindhe, J.; and Hellden, L.: Effect of Tetracycline and/or Scaling on Human Periodontal Disease, J Clin Periodontol5:246-271, 1978.
25.
Slots, J.; Mashimo, P.; Levine, M.J.; and Genco, R.J.: Periodontal Therapy in Humans. I. Microbiological and Clinical Effects of a Single Course of Periodontal Scaling and Root Planing, and of Adjunctive Tetracycline Therapy, J Periodontol59:495-509, 1979.
26.
Gordon, J.M. ; Walker, C.B.; Goodson , J.M.; and Socransky , S.S.: Sensitive Assay for Measuring Tetracycline in Gingival Crevice Fluid, Antimicrob Agents Chemother17:193-198, 1980.
27.
Department of Pharmacology: The Pharmacology of Baicalin, Arch Xian Medical College No . 5:30-34, 1958.
