The ability of suspensions of natural supragingival plaque, artificial plaque, and Streptococcus mutans KIR to hydrolyze sodium monofluorophosphate, Na2PO 3F (MFP), was investigated using a fluoride-selective electrode. S. mutans KIR cells produced minimal hydrolysis. Enzymes in plaque suspensions rapidly hydrolyzed MFP to liberate fluoride ion, a possible mechanism for the cariostatic action of monofluorophosphate dentifrices.
Get full access to this article
View all access options for this article.
References
1.
Ingram, G.S. : Some Factors Affecting the Interaction of Hydroxyapatite with Sodium Monofluorophosphate , Caries Res7:315-323, 1973.
2.
Ericsson, Y. : The Mechanism of the Monofluorophosphate Action on Hydroxyapatite and Dental Enamel, Acta Odontol Scand21:341-358, 1963.
3.
Pearce, E.I.F. : A Laboratory Evaluation of New Zealand Fluoride Toothpastes, NZ Dent J70:98-108, 1974.
4.
Pearce, E.I.F. and More, R.D.: Uptake of Fluoride by Enamel from Monofluorophosphate Dentifrices, Caries Res9:459-475, 1975.
5.
Grn, P. ; Brudevold, F.; and Aasenden, R.: Monofluorophosphate Interaction with Hydroxyapatite and Intact Enamel , Caries Res5:202-214, 1971.
6.
Ericsson, Y. : Biologic Splitting of PO3F Ions, Caries Res1:144-152, 1967.
7.
Fernley, H.N. and Walker, P.G.: Studies on Alkaline Phosphatase. Inhibition by Phosphate Derivatives and the Substrate Specificity, Biochem J140:1011-1018, 1967 .
8.
Bessy, O.A.; Lowry, O.H.; and Brock, M.J.: A Method for the Rapid Determination of Alkaline Phosphatase with Five Cubic Millimeters of Serum, J Biol Chem164:321-329, 1946.
9.
Greenman, J. and Melville, T.H.: Phosphatase Activity in Strains of Streptococcus mutans, Arch Oral Biol23 :965-970, 1978.
10.
Pearce, E.I.F. and Jenkins, G.N.: The Decomposition of Monofluorophosphate by Enzymes in Whole Human Saliva, Arch Oral Biol22:405-407, 1977.
11.
Fitzgerald, R.J.: Preliminary Studies on the Presence of Acid Phosphatase in Certain Oral Microorganisms, J Dent Res31:189-194, 1952.
12.
Cornish, C.J. and Posen, G.: Human Salivary Alkaline Phosphatase , Clin Chim Acta20:387-391, 1968.
13.
Greenman, J. ; Melville, T.H.; and Appleton , J.: The Localization of Phosphatase Activity in Two Oral Strains of Streptococcus, Arch Oral Biol25:759-765, 1980.
14.
Fejerskov, 0.; Thylstrup, A.; and Larsen, J.J.: Rational Use of Fluorides in Caries Prevention. A Concept Based on Possible Cariostatic Mechanisms, Acta Odontol Scand39:241-249, 1981.
15.
Luoma, H.: Phosphorus Translocation Between Enamel and Streptococcus mutans in the Presence of Sucrose and Fluoride with Observations on the Acid Phosphatase of S. mutans , Caries Res14:248-257, 1980.
