The aim of the present study was to examine idiopathic lichen planus for possible changes in the serum concentration of the immunological marker β2 microglobulin (β2m), a component of HLA antigens. It was shown that serum levels of β2m were not different in lichen planus from those in controls. Although these findings do not support major systemic immunopathological changes in lichen planus, they do not exclude the involvement of local immune mechanisms.
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References
1.
Black, M.M.: What is Going on in Lichen Planus? Clin Exp Dermatol2:303-310, 1977.
2.
Davies, M.G. ; Gorkiewicz, A.; Knight , A.; and Marks, R.: Is There a Relationship Between Lupus Erythematosus and Lichen Planus? Br J Dermatol96:145-154, 1977.
3.
Stingl, G. and Holubar, K.: Co-existence of Lichen Planus and Bullous Pemphigoid, Br J Dermatol93:313-320, 1975.
4.
Samman, P.D. : Discussion of Thymoma, Acquired Hypogammaglobulinaemia , Lichen Planus and Alopecia Areata, Proc Roy Soc Med67:198, 1974.
5.
Aronson, I.K. ; Soltani, K.; Paik , K.-I.; Rubenstein, D.; and Lorincz, A.L.: Triad of Lichen Planus, Myasthenia Gravis and Thymoma, Arch Dermatol114:255-258, 1978.
6.
Saurat, J.H. ; Gluckman, E.; Bussel , A.; Didierjean, L.; and Puissant, A.: The Lichen Planus-like Eruption After Bone Marrow Transplantation, Br J Dermatol92 :675-681, 1975.
7.
Fellner, M.J. : Lichen Planus, Int J Dermatol19:71-75, 1980.
8.
Tan, R.S.H. ; Hayes, J.P.; and Byrom, N.A.: Identification of Lymphoid Cells in the Cutaneous Infiltrate of Skin Reticuloses and Lichen Planus, Br J Dermatol93(Suppl. 11):16, 1975.
9.
Walker, D.M. : Identification of Subpopulations of Lymphocytes and Macrophages in the Infiltrate of Lichen Planus Lesions of Skin and Oral Mucosa, Br J Dermatol94:529-534, 1976.
10.
Alaria, A.; Ortonne, J.; Schmitt, D.; and Thivolet, J.; Lichen Planus: Study with Antihuman T Lymphocyte Antigen (anti-HTLA) Serum on Frozen Sections , Br J Dermatol98:601-604, 1978.
11.
Braathen, L.R. ; Dal, B.L.; and Mellbye, O.J.: Immunological in situ Identification of the Lymphoid Cells in the Skin Infiltrate of Lichen Planus, Clin Exp Dermatol4:175-185, 1979.
12.
Sarkany, 1. and Gaylorde, P.M.: The Pathogenesis of Lichen Planus , Br J Dermatol87:81, 1972.
13.
Helander, I. and Hopsu-Havu, V.K.: Cell-mediated Immunity in Lichen Planus , Arch Dermatol Res258:1-7, 1977.
14.
Lowe, N.J.; Cudworth, A.G.; and Woodrow, J.C.: HLA Antigens in Lichen Planus, Br J Dermatol95:169-171, 1976.
15.
Bernier, G.M. and Fanger, M.W.: Synthesis of β2-microglobulin by Stimulated Lymphocytes, J Immunol109 :407-409, 1972.
16.
Nilsson, K. ; Evrin, P.E.; and Welsh, I.: Production of β2-microglobulin by Normal and Malignant Human Cell Lines and Peripheral Lymphocytes, Transpl Rev21:53-84, 1974.
17.
Kin, K. ; Kasahara, T.; Hoh , Y.; Sakurabayashi, I.; Kawai, T.; and Morita, M.: β2-microglobulin Production by Highly Purified Human T and B Lymphocytes in Cell Culture Stimulated with Various Mitogens, Immunology36: 47-54, 1979.
18.
Evrin, P.E. and Wibell, L.: Serum Beta 2 Microglobulin in Various Disorders , Clin Chim Acta43:183-187, 1973.
19.
Michalski, J.P.; Daniels, T.E.; Talal , N.; and Grey, H.M.: β2 Microglobulin and Lymphocytic Infiltration in Sjogren's Syndrome, N Engl J Med293:1228-1231, 1975.
20.
Shuster, J. ; Gold, P.; and Poulik, M.D.: β2-microglobulin Levels in Cancerous and Other Disease States, Clin Chim Acta67:307-313, 1976.
21.
Weissell, M. ; Scherak, O.; Fritsche , H.; and Kolarz, G.: Serum Beta 2 Microglobulin and SLE, Arthritis Rheum19:968,1976.
22.
Wibell, L.; Evrin, P.E.; and Berggard, I.: Serum Beta 2 Microglobulin in Renal Disease, Nephron10:320-321, 1973.
23.
Vincent, C. and Revillard, J.P.: Comparison of Radioimmunoassay and Lymphocytoxicity Inhibition Techniques for the Determination of β2 Microglobulin, J Immunol Methods10:253-259, 1976.
24.
Strom, T.; Evrin, P.E.; and Karlsson, A.: Serum Beta-2 Microglobulin in Sjogren's Syndrome, Scand J Rheumatol7:97-100,1978.
25.
Descos, L.; Andre, C.; Beorchia, S.; Vincent, C.; and Revillard, J.P.: Serum Levels of β2 Microglobulin - A New Marker of Activity in Crohn's Disease, N Engl J Med301: 440-441, 1979.
26.
Manicourt, D.H. and Orloff, S.: Serum Levels of β2microglobulin in Crohn's Disease, N Engl J Med302:696, 1980.
27.
Amlot, P.L. and Adinolfi, M.: Serum β2-microglobulin and Its Prognostic Value in Lymphomas, Eur J Cancer15: 791-796, 1979.
28.
Child, J.A. ; Spati, B.; Illingworth , S.; Barnard, D.; Corbett, S.; Simmons, A.V.; Stone, J.; Worthy, S.; and Cooper, E.H.: Serum Beta-2-microglobulin and C-reactive Protein in the Monitoring of Lymphomas. Findings in a Multicentre Study and Experience in Selected Patients, Cancer45:318-326, 1980.
29.
Karlsson, F.A. ; Wibell, L.; and Evrin, P.E.: β2-microglobulin in Clinical Medicine, Scand J Clin Lab Invest (Suppl. 154)40:27-37, 1980.
30.
Scully, C.: Serum β2 Microglobulin in Recurrent Aphthous Stomatitis and Behcet's Syndrome , Clin Exp Dermatol, In press.
31.
Griffith, M. ; Kaufman, H.S.; and Silverman , S.: Studies on Oral Lichen Planus: I. Serum Immunoglobulins and Complement, J Dent Res53:623-626, 1974.
32.
Stankler, L. : Deficiency of Circulating IgA and IgM in Adult Patients with Lichen Planus , Br J Dermatol93:25-27, 1975.
33.
Jacyk, W.K. and Greenwood, B.M.: Serum Immunoglobulins in Nigerian Patients with Lichen Planus, Clin Exp Dermatol3:83-84, 1978.
Scully, C.: Serum IgG, IgA, IgM, IgD, and IgE in Lichen Planus: No Evidence for a Humoral Immunodeficiency, Clin Exp Dermatol, In press.
36.
Baart de la Faille-Kuyper, E.H. and Baart de la Faille, H.: An Immunofluorescence Study of Lichen Planus, Br J Dermatol90:365-371, 1974.
37.
Abell, E.; Presbury, D.G.C.; Marks, R.; and Ram-Narain, D.: The Diagnostic Significance of Immunoglobulin and Fibrin Deposition in Lichen Planus, Br J Dermatol93 :17-24, 1975.
38.
Varelzidis, A.; Tosca, A.; Perissios , A.; and Capet-Anakis , J.: Immunohistochemistry in Lichen Planus, Dermatologica159:137-144, 1979.
39.
Holmstrup, P. and Soborg, M.: Cellular Hypersensitivity to Oral Lichen Planus Lesions in vitro, Acta Allergol32 :304-315, 1977.
