The phagocytic and killing capacities of human blood, gingival crevicular, and salivary polymorphonuclear leukocytes for oral streptococci have been examined. Crevicudar and salivary leukocytes were active in phagocytosis and killing of oral streptococci, but were impaired in these respects compared with blood leukocytes.
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References
1.
Carlsson, J. : Presence of Various Types of Nonhaemolytic Streptococci in Dental Plaque and in Other Sites of the Oral Cavity in Man , Odontol Revy18:55-74, 1967.
2.
Gibbons, R.J. and Van Houte , J.: Dental Caries, Ann Rev Med26:121-136, 1975.
3.
Irving, J.T. ; Socransky, S.S.; and Heeley, J.D.: Histological Changes in Experimental Periodontal Disease in Gnotobiotic Rats and Conventional Hamsters, J Periodont Res9:73-80, 1974.
4.
Scully, C. and Lehner, T.: Opsonisation, Phagocytosis and Killing of Streptococcus mutans by Polymorphonuclear Leukocytes in Relation to Dental Caries in the Rhesus Monkey (Macaca mulatta) , Arch Oral Biol24:307-312, 1979.
5.
Scully, C. and Challacombe, S.J. : The Migration of 111Indium-labelled Polymorphonuclear Leukocytes into the Oral Cavity in the Rhesus Monkey, J Periodont Res14 :475-481, 1979.
6.
NEWMAN, H.N.: Neutrophils and IgG at the Host-Plaque Interface of Children's Teeth, J Periodontol 51:642-651, 1980. 7. GENCO, R.J. and CIANCIOLA, L.J.: Relationship of the Neutrophil to Host Resistance in Periodontal Disease, Alpha Omegan 10:31-40,1977.
7.
Skapski, H. and Lehner, T.: A Crevicular Washing Method for Investigating Immune Components of Crevicular Fluid in Man, J Periodont Res11:19-24, 1976.
8.
Kowolik, M.J. and Raeburn, J.A.: Functional Integrity of Gingival Crevicular Neutrophil Polymorphonuclear Leukocytes as Demonstrated by Nitro Blue Tetrazolium Reduction, J Periodont Res15:483-491, 1980.
9.
Wilton, J.M. ; Renggli, H.H.; and Lehner, T.: A Functional Comparison of Blood and Gingival Inflammatory Polymorphonuclear Leukocytes in Man, Clin Exp Immunol27:152-158, 1977.
10.
Murray, P.A. and Patters, M.R.: Gingival Crevice Neutrophil Function in Periodontal Lesions, J Periodont Res15: 463-469, 1980.
11.
Sonis, S.T. ; Mirando, D.; Stelos , P.; and Lamster, I.B.: Capacity of Human Oral Leukocytes to Mediate Antibody-dependent Cell-mediated Cytotoxicity , Arch Oral Biol24 :235-237, 1979.
12.
Scully, C. and Lehner, T.: Bacterial and Strain Specificities in Opsonisation, Phagocytosis and Killing of Streptococcus mutans, Clin Exp Immunol35:128-132, 1978.
13.
Fallon, H.J. ; Frei, E.; Davidson , J.D.; Trier, J.S.; and Burk, D.J.: Leukocyte Preparations from Human Blood; Evaluation of Their Morphologic and Metabolic State, J Lab Clin Med59:779-791, 1962.
14.
Miles, A.A. ; Misra, S.S.; and Irwin, J.O.: Estimation of Bactericidal Power of Blood , J Hyg38:732-749, 1938.
15.
Scully, C.: Transport and Function of Polymorphonuclear Leukocytes in Crevicular Fluid . In: Borderland Between Caries and Periodontal Disease , 2nd European Symposium, Lehner, T. and Cimasoni, G., Eds., London: Academic Press, 1980, pp. 69-81.
16.
Smith, D.L. and Rommel, F.: A Rapid Micromethod for the Simultaneous Determination of Phagocytic-Microbicidal Activity of Human Peripheral Blood Leukocytes in vitro, J Immunol Meth17:241-247, 1977.
17.
Weisblum, B. : Fluorescent Probes of Chromosomal DNA Structure - Three Classes of Acridines, Cold Spring Harbor Symp., Quant Biol38:441, 1973.
18.
Passo, S.A. ; Tsai, C.C.; McArthur , W.P.: LEIFER, C.; and TAICHMAN, N.S.: Interaction of Inflammatory Cells and Oral Micro-organisms . IX. The Bactericidal Effects of Human Polymorphonuclear Leukocytes, J Periodont Res15 :476-482, 1980.
19.
Attstrom, R. and Egelberg, J.: Emigration of Blood Neutrophils and Monocytes into the Gingival Crevice, J Periodont Res5:48-55, 1970.
20.
Sharry, J.J. and Krasse, B.: Observations on the Origin of Salivary Leukocytes , Acta Odontol Scand18:347-358, 1960.
21.
Schiott, C.R. and Loë, H.: The Origin and Variation in Number of Leukocytes in the Human Saliva, J Periodont Res5:36-41, 1970.
22.
Schroeder, H.E.: The Structure and Relationship of Plaque to the Hard and Soft Tissues. Electron Microscopic Interpretations, Int Dent J20:253-281, 1970.
23.
Lange, D. and Schroeder, H.W.: Cytochemistry and Ultrastructure of Gingival Sulcus Cells, Helvet Odont Acta15: 65-69, 1971.
24.
Baehni, P.; Listgarten, M.A.; Taichman, N.S.; and McArthur, W.P.: Electron Microscopic Study of the Interaction of Oral Micro-organisms with Polymorphonuclear Leukocytes, Arch Oral Biol22:685-692,1977.
25.
Scully, C.: Comparative Opsonic Activity for Streptococcus mutans in Oral Fluids, and Phagocytic Activity of Blood, Crevicular and Salivary Polymorphonuclear Leukocytes in Rhesus Monkeys, Immunology39:101-107, 1980.
26.
Stossel, T.P. : The Mechanism of Leukocyte Locomotion. In: Leukocyte Chemotaxis, Gallin, J.I. and Quie, P.G., Eds., New York: Raven Press, 1978, pp. 143-160.
27.
Orban, B. and Weinmann, J.P.: Cellular Elements of Saliva and Their Possible Role in Caries, J Dent Res18:258, 1939.
28.
Orban, B. and Weinmann, J.P.: The Cellular Elements of the Saliva and Their Possible Role in Caries , JADA26 :2008-2017, 1939 .
29.
Rovelstad, G.H. : The Morphological, Physical and Biochemical Characteristics of Salivary Corpuscles. Ph.D. Thesis, Northwestern University, Evanston, IL, 1960.
30.
Eichel, B. and Lisanti, V.G.: Leukocyte Metabolism in Human Saliva, Arch Oral Biol9:299-314, 1964.
31.
Sims, W.: The Concept of Immunity in Dental Caries. II. Specific Immune Responses , Oral Surg34:69-86, 1972.
32.
Willsmore, N.N.: A Study of the Osmotic Pressure and Viscosity of Saliva and Their Relation to Common Oral Conditions, Aust Dent J41:161-195, 1937.