Unilateral extraction of rat molars was followed by degeneration of type A temporomandibular joint synovial lining cells. The uptake of intravenously injected HRP decreased in accordance with the degree of degenerative change. Normal passage of proteins from blood to joint cavity appears to be controlled by the synovium, especially by type A cells. This study suggests that, with certain TMJ disturbances, control of protein transport may be altered.
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