Searching for an experimental model simulating the root canal, a two-stage procedure was evolved using polyethylene tubes implanted subcutaneously in rabbits. The reaction to the model was histologically evaluated, and the rate of release of macromolecules from the tubes was studied using radio-labeled endotoxin and albumin. The model proved suitable for evaluating an animal's tissue response to the slow and prolonged influx of foreign fluids.
Get full access to this article
View all access options for this article.
References
1.
Torneck, C.D. : Reaction of Hamster Tissue to Drugs used in Sterilisation of the Root Canal, Oral Surg14:730-747, 1961.
2.
Makkes, P.C. : THODEN van VELZEN, S.K.; and van den HOOFF, A.: Short-term Tissue Reactions to Enclosed Glutaraldehyde-fixed Tissue, Oral Surg46:854-861, 1978.
3.
Hunter, W.M. and Greenwood, F.C.: Preparation of Iodine-131-labelled Human Growth Hormone of High Specific Activity, Nature194:495-496, 1962.
4.
Makkes, P.C. ; Thoden van Velzen , S.K.; Wesselink, P.R.; and De Greeve, P.C.M.: Polyethylene Tubes as a Model for the Root Canal, Oral Surg44:293-300, 1977.
5.
Green, E.N.: Microscopic Investigation of Root Canal Diameters, JADA57:636-644, 1958.
