The circulatory uptake and urinary excretion of topical fluoride were investigated by applying a sodium fluoride solution containing 18F for six min to healthy gingiva of four adult dogs. Blood and urine samples were taken at regular intervals.
Maximal fluoride in blood represented 0.02-0.05% of the applied dose and occurred four min after completion of the application. By 6.0 h, 0.02-0.06% of the applied dose had been excreted in urine. Preliminary data showed that this represented about 8.8% of the fluoride absorbed through the gingiva.
Get full access to this article
View all access options for this article.
References
1.
Hellstrom, I. : Fluoride Retention Following Sodium Fluoride Mouthwashing, Acta Odont Scand18:263-278, 1960.
2.
Ericsson, Y. : Fluorides in Dentifrices, Acta Odont Scand19:41-75, 1961.
3.
McDougall, W. : Penetration Pathways of a Topically-applied Foreign Protein into Rat Gingiva, J Perio Res6:89-99, 1971.
4.
Schwartz, J. ; Stinson F.; and Parker, R.: The Passage of Tritiated Bacterial Endotoxin Across Intact Gingival Crevicular Epithelium , JPerio43:270-276, 1972.
5.
Egelberg, J. : Diffusion of Histamine into the Gingival Crevice and Through the Crevicular Epithelium, Acta Odont Scand21 :271-282,1963.
6.
International Workshop on Fluorides and Dental Caries Reductions, Forrester, D. and Schulz, E., Eds., Baltimore, MD: University of Maryland, 1974.
7.
Loë, H. and Silness, J.: Periodontal Disease in Pregnancy. I. Prevalence and Severity, Acta Odont Scand21:535-551, 1963.
8.
Silness, J. and Loë, H.: Periodontal Disease in Pregnancy. II. Correlation Between Oral Hygiene and Periodontal Condition, Acta Odont Scand22:121-135, 1960. 9. Noble, R. and Gregerson, M.: Blood Volume in Clinical Shock. I. Mixing Time and Disappearance Rates of T-1824 in Normal Patients and Patients in Shock, J Clin Invest25:158-171, 1946.
9.
Chinard, F. : Estimation of Plasma Volume by Dye Dilution Methods, Methods in Med Res4:38.48, 1951 .
10.
Tilbury, R. ; Dahl, J.; and Mamacos, J.: Fluoride-18 Production for Medical Use by Helium-3 Bombardment of Water, Int J Appl Radiation and Isotopes21:277-281, 1970.
11.
Schweinsberger, R. and Muhler, J.: Urinary Fluorine Levels in Children Following the Clinical Use of a Stannous Fluoride-containing Dentifrice, J Dent Res35: 760-762, 1956.
12.
Duckworth, R.: Urinary Excretion of Fluoride from a Dentifrice Containing Stannous Fluoride, IADR Progr & Abst42: No. 20, 1963.
13.
Gabler, W.: Absorption of Fluoride Through the Oral Mucosa of Rats, Arch Oral Biol13:619-623, 1968.
14.
Patten, J.; Whitford, G.; Stringer, G.; and Pashley, D.: Oral Absorption of Radioactive Fluoride and Iodide in Rats, Arch Oral Biol, In press, 1981.
15.
Carlson, C. ; Armstrong, W.; Singer , L.; and Hinshaw, L.: Renal Excretion of Radiofluoride in the Dog , Am J Physiol198:829-832, 1960.
16.
Birkeland, J. and Lokken, P.: The Pharmacokinetics of Fluoride in Mouth Rinses as Indicated by a Reference Substance (51Cr-EDTA), Caries Res6:325-333, 1972.
17.
Wallace-Durbin, P.: The Metabolism of Fluoride in the Rat Using 18F as a Tracer, J Dent Res33:796-797, 1954.
18.
Smith, F.: Metabolism of Inorganic Fluoride. In: Pharmacology of Fluorides, Part I. Smith, F., Ed., New York: Springer-Verlag, 1966, pp. 53-140.
19.
Ekstrand, J. ; Alvan, G.; Boreus , L.; and Norlin, A.: Pharmacokinetics of Fluoride in Man after Single and Multiple Doses, Europ J Clin Pharmacol12:311-317, 1977.
20.
Ekstrand, J. ; Ehrnebo, M.; and Boreus, L.: Fluoride Bioavailability after Intravenous and Oral Administration, Clin Pharmacol and Ther23:329-337, 1978.
