The quantities of lactate and acetate produced by human dental plaque were compared before and after five-minute exposures to 1% sodium fluoride gel. A single topical application of the gel increased plaque fluoride by about 700 ppm, 79% of which was lost after six h. Gel use significantly reduced plaque L(+)-lactate production in vitro, and the production of L(+)- and D(-)-lactate and acetate in situ.
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