An in vitro system was used to study the detoxifying potential of H2O2 on bacterial endotoxin. L929 fibroblasts were exposed to H202-treated and -untreated endotoxin. Growth and viability assays were made at 24, 48, 72, and 96 h. The cultures exposed to H202-treated endotoxin showed a normal growth rate, whereas the cultures exposed to untreated endotoxin displayed a substantial reduction in growth. Implications are presented as to the potential role of H202 in the pathogenesis and treatment of periodontal disease.
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