Human subjects were examined for caries activity and for naturally-occurring salivary IgA of glycerol-teichoic acid (TA) specificity by an enzyme-linked immunosorbent assay. Subjects free of active caries produced higher levels of anti-TA in their saliva than persons with one or more active carious lesions.
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References
1.
Bowen, W.H.; Genco, R.J.; and O'Brien, T.C. : Immunologic Aspects of Dental Caries, Washington: Information Retrieval, Inc. , 1976.
2.
Emmings, F.G. ; Evans, R.T.; and Genco, R.J.: Immunization of Macaca fascicularis and Macaca irus Monkeys with Streptococcus mutans. Specificity of Antibody Responses in Saliva, J Dent Res55:C181-C192, 1976 .
3.
McGhee, J.R. ; Michalek, S.M.; Webb , J.; Navia, J.M.; Rahman, A.F.R.; and Legler , D.W.: Effective Immunity to Dental Caries. Protection of Gnotobiotic Rats by Local Immunization with Streptococcus mutans, J Immunol114:300-305, 1975.
4.
Michalek, S.M. ; McGhee, J.R.; Mestecky , J.; Arnold, R.R.; and Bozzo, L.: Ingestion of Streptococcus mutans Induces Secretory Immunoglobulin A and Caries Immunity , Science192:1238-1240, 1975 .
5.
Taubman, M.A. and Smith, D.J.: Effect of Local Immunization with Streptococcus mutans on Induction of Salivary Immunoglobulin A Antibody and Experimental Dental Caries in Rats, Infect Immun9 :1079-1089, 1974.
6.
Michalek, S.M. ; McGhee, J.R.; and Babb, J.L.: Effective Immunity to Dental Caries: Dose-dependent Studies of Secretory Immunity by Oral Administration of Streptococcus mutans to Rats, Infect Immun19: 217-224, 1978.
7.
Russell, M.W. ; Challacombe, S.J.; and Lehner, T.: Serum Glucosyltransferase Inhibiting Antibodies and Dental Caries in Rhesus Monkeys Immunized Against Streptococcus mutans , Immunology30:619-627, 1976.
8.
Smith, D.J.; Taubman, M.A.; and Eber-Sole, J.L.: Effect of Oral Administration of Glucosyltransferase Antigens on Experimental Dental Caries, Infect Immun26:82-89, 1979.
9.
Smith, D.J.; Taubman, M.A.; and Eber-Sole, J.L.: Local and Systemic Antibody Response to Oral Administration of Glucosyltransferase Antigen Complex, Infect Immun28:441-450, 1980.
10.
Everhart, D.L. ; Klapper, B.; Carter , W.H.; and Moss, S.: Evaluation of Dental Caries Experience and Salivary IgA in Children Ages Three to Seven , Caries Res11 :211-215, 1977.
11.
Bratthall, D.; Gahnberg, L.; and Krasse, B.: Method for Detecting IgA Antibodies to Streptococcus mutans in Parotid Saliva, Arch Oral Biol23:843-849, 1978.
12.
Bammann, L.L. and Gibbons, R.J.: Immunoglobulin A Antibodies Reactive with Streptococcus mutans in Saliva of Adults, Children, and Predentate Infants, J Clin Microbiol10:538-543, 1979.
13.
Knox, K.W. and Wicken, A.J.: Immunological Properties of Teichoic Acids, Bacterial Rev37:215-257, 1973.
14.
Chorpenning, F.W.; Cooper, H.R.; and Rosen, S.: Cross Reactions of Streptococcus mutans Due to Cell Wall Teichoic Acid, Infect Immun12:586-591, 1975.
15.
Decker, G.P. ; Chorpenning, F.W.; and Frederick , G.T.: Naturally-occurring antibodies to Bacillary Teichoic Acids, J Immunol108:214-222,1972.
16.
Rozmiarek, H. ; Bolton, F.W.; and Chorpenning , F.W.: Environmental Origin of Natural Antibodies to Teichoic Acid, Infect Immun16:505-509, 1977.
17.
Markham, J.L. ; Knox, K.W.; Wicken , A.J.; and Hewitt, M.J.: Formation of Extracellular Lipoteichoic Acid by Oral Streptococci and Lactobacilli, Infect Immun12: 378-386,1975.
18.
Ciardi, J.; Rolla, G.; Bowen, W.; and Reilly, J.: Adsorption of Streptococcus mutans Lipoteichoic Acid to Hydroxyapatite , Scand J Dent Res85:387-391, 1977.
19.
Bolton, R.W. : Adherence of Oral Streptococci to Hydroxyapatite in vitro via Glycerol-teichoic Acid, Arch Oral Biol25:111-114, 1980.
20.
ROLLA, G.: Inhibition of Absorption-general Considerations. In: Microbial Aspects of Dental Caries, Stiles, H.M., Loesche, W.J., and O'Brien, T.C., Eds., Washington: Information Retrieval, Inc., 1976, pp. 309-324. 21. COOPER, H.R.; CHORPENNING, F.W.; and ROSEN, S.: Lipid-free Glycerol-teichoic Acids with Potent Membrane Binding Activity, Infect Immun 19:462-469, 1978.
21.
Engvall, E. and Perlmann, P.: Enzyme-linked Immunosorbent Assay. ELISA III. Quantitation of Specific Antibodies by Enzyme-labeled Anti-immunoglobulin in Antigen-coated Tubes, J Immunol109 :129-135, 1972.
22.
McCarty, M. : The Occurrence of Poly-glycerophosphate as an Antigenic Component of Various Gram-positive Bacterial Species, J Exp Med109:361-368, 1959.
23.
ARNOLD, R.R.; MESTECKY, J.; and McGHEE, J.R.: Naturally-occurring Secretory Immunoglobulin A Antibodies to Streptococcus mutans in Human Colostrum and Saliva, Infect Immun 14:355-362, 1976. 25. WALKER, W.A. and ISSELBACKER, K.J.: Intestinal Antibodies, New Eng J Med 14: 767-773. 1977.
24.
Mestecky, J. ; McGhee, J.R.; Arnold , R.R.; Michalek, S.M.; Prince, S.J.; and Babb, J.L.: Selective Induction of an Immune Response in Human External Secretions by Ingestion of Bacterial Antigen, J Clin Invest61:731-737, 1978.
25.
Challacombe, S.J.: Salivary IgA Antibodies to Antigens from Streptococcus mutans in Human Dental Caries, Adv Exp Biol Med107:355-367,1978.
26.
Huis in t' Veld, J. ; Bannet, D. ; Helder-Man, S.P.; Carmargo, P.S.; and Backer-Dirks, 0. : Antibodies Against Streptococcus mutans and Glucosyltransferases in Caries-free and Caries-active Military Recruits. In: Secretory Immunity and Infection, McGhee, J.R., Mestecky, J., and Babb, J.L. Eds., New York: Plenum Press, 1978, pp. 369-381.
27.
Crawford, J.M. ; Taubman, M.A.; and Smith, D.J.: Minor Salivary Glands as a Major Source of Secretory Immunoglobulin A in the Human Oral Cavity , Science190: 1206-1209, 1975 .
28.
Everhart, D.L. ; Rothenberg, K.; Carter , W.H.; and Klapper, B.: The Determination of Antibody to Streptococcus mutans Serotypes in Saliva for Children Ages Three to Seven Years, J Dent Res57 :631-635, 1978.
29.
Everhart, D.L. ; Girgsby, W.R.; and Carter, W.H.: Evaluation of Dental Caries Experience and Salivary Immunoglobulins in Whole Saliva, J Dent Res51:1487-1491, 1972 .
30.
Everhart, D.L. ; Girgsby, W.R.; and Carter, W.H.: Human Dental Caries Experience Related to Age, Sex, Race, and Certain Salivary Properties, J Dent Res52:242-247, 1973.
31.
Orstavik, P. and Brandtzaeg, P.: Secretion of Parotid IgA in Relation to Gingival Inflammation and Dental Caries Experiments in Man, Arch Oral Biol20: 701-705, 1975.
32.
Chiang, T.M. ; Alkan, M.L.; and Beachey, E.H.: Binding of Lipo-teichoic Acid of Group A Streptococci to Isolated Human Erythrocyte Membranes , Infect Immun26: 316-321, 1979.
33.
Beachey, E.H. ; Dale, J.B.; Grebe , S.; Ahmed, A.; Simpson, W.A.; and Ofek, I.: Lymphocyte Binding and T Cell Mitogenic Properties of Group A Streptococcal Lipoteichoic Acid , J Immunol122:189-195, 1979.
34.
Wicken, A.J. ; Gibbens, J.W.; and Knox, K.W.: Anti-teichoic Acid Antibodies and Non-treponemal Serological Tests for Syphilis, Infect Immun5:982-984, 1972.