The biosynthesis of radioactive prostaglandin E2 (PGE2) and F2αfrom (] .14C) arachidonic acid has been demonstrated in the microsomal fraction of gingiva of patients with chronic periodontitis in vitro. 14C corresponding to unmetabolized arachidonic acid in three separate incubations was 83, 66, and 83%, and that corresponding to both PGE2 and PGF2α was 8, 22, and 9% of the total radioactivity recovered after chromatography. The ratios of PGE2 to PGF 2αwere found to be 6:1, 6:1, and 3:1, respectively.
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