Cell kinetics of rat molar periodontal ligament (PDL) during orthodontically-induced osteogenesis revealed: 1) primary growth fraction of 59%, 2) proliferating cells from throughout the PDL migrate toward the bone surface, 3) preosteoblasts, capable of forming osteoblasts without synthesizing DNA, are present in the PDL, 4) osteoblasts are derived from local PDL cells, and 5) cell death is a characteristic feature of the osteogenic response.
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References
1.
Macapanpan, L.C.; Weinmann, J.P.; and Brodie, A.G.: Early Tissue Changes Following Tooth Movement in Rats, Angle Orthod25 :79-95, 1954.
2.
Baumrind, S. and Buck, D.L.: Rate Changes in Cell Replication and Protein Synthesis in the Periodontal Ligament Incident to Tooth Movement , Am J Orthod57 :109-131,1970.
3.
Roberts, W.E. and Jee, W.S.S.: Cell Kinetics of Orthodontically-stimulated and Non-stimulated Periodontal Ligament in the Rat, Arch Oral Biol19:17-21, 1974.
4.
Roberts, W.E. ; Chase, D.C.; and Jee , W.S.S.: Counts of Labeled Mitoses in the Orthodontically-stimulated Periodontal Ligament of the Rat , Arch Oral Biol19 :665-670,1974.
5.
Yee, J.A. ; Kimmel, D.B.; and Jee , W.S.S.: Periodontal Ligament Cell Kinetics Following Orthodontic Tooth Movement, Cell Tiss Kinet9:293-302,1976.
6.
Rodan, G.A.; Bourret, L.A.; and Norton, L.A.: DNA Synthesis in Cartilage Cells is Stimulated by Oscillating Electric Fields , Science199:690-692, 1978.
7.
Norton, LA; Rodan, G.A.; and Bourret, L.A.: Epiphyseal Cartilage cAMP Changes Produced by Electrical and Mechanical Perturbations , Clin Orthop124 :59-68, 1977.
8.
Davidovitch, Z.; Montgomery, P.C.; and Eckerdal , C.O.; and Gustafson, G.T.: Cellular Localization of Cyclic AMP in Periodontal Tissues During Experimental Tooth Movement in Cats, Calcif Tiss Res19: 317-329, 1976.
9.
Frost, H.M. : Bone Remodeling and Its Relationship to Metabolic Bone Diseases. C. C. Thomas, Ed., Springfield, 1973.
10.
Roberts, W.E. : Cell Population Dynamics of Periodontal Ligament Stimulated with Parathyroid Extract, Am J Anat143 :465-471,1975.
11.
Roberts, W.E. : Cell Kinetic Nature and Diurnal Periodicity of the Rat Periodontal Ligament, Arch Oral Biol20:465-471, 1975.
12.
Melcher, A.H. : Periodontal Ligament. In: Orban's Oral Histology and Embryology, S. N. Bhaskar, Ed., St. Louis: C. V. Mosby, 1976.
13.
Roberts, W.E.: Advanced Techniques for Quantitating Bone Cell Kinetics and Cell Population Dynamics. In: Bone Morphometry, Z. F. G. Jaworski, Ed., Ottawa: University of Ottawa Press, 1976.
14.
Kimmel, D.B. and Jee, W.S.S.: A Rapid Plastic Embedding Technique for Preparation of Three-micron Thick Sections of Decalcified Hard Tissue , Stain Technol50:83-86, 1975.
15.
Weiss, R.; Stahl, S.S.; and Tonna, E.A.: Functional Demands on the Cell Proliferative Activity of the Rat Periodontium Studied Autoradiographically, J Dent Res47:1153-1157, 1968.
16.
Tonna, EA ; Weiss, R.; and Stahl, S.S.: The Cell Proliferative Activity of Parodontal Tissues in Aging Mice , Arch Osal Biol17 :969-982, 1972.
17.
Tonna, E.A. and Stahl, S.S.: A (3H)-Thymidine Autoradiographic Study of Cell Proliferative Activity of Injured Parodontal Tissues of Five-week-old Mice, Arch Oral Biol18:617-627, 1973.
18.
Cleaver, J.E.: Thymidine Metabolism and Cell Kinetics, Amsterdam : North Holland, 1967.
19.
Kember, N.F. : Cell Division in Endochondral Ossification , J Bone Jt Surg42B :824-839, 1960.
20.
Hall, B.K.: The Origin and Fate of Osteoclasts, Anat Rec183:1-11, 1975.
21.
Freidenstein, A.Y.: Induction of Bone Tissue by Transitional Epithelium, Clin Orthop59:21-37,1968.
22.
Van Furth, R.: The Origin and Turnover of Promonocytes, Monocytes and Macrophages in Normal Mice. In: Mononuclear Phagocytes, R. Van Furth, Ed., Philadelphia: F. A. Davis Co., 1970, pp. 151-165.
