The ability of human oral bacteria to inhibit Streptococcus mutans was studied under a variety of in vitro conditions using an agar overlay assay. Extensive inherent variability in microbial antagonism by certain organisms was demonstrated. Antagonistic activity was also significantly influenced by changes in the assay conditions.
Get full access to this article
View all access options for this article.
References
1.
Sanders, W.E. , Jr.: Bacterial Interference. I. Its Occurrence Among the Respiratory Tract Flora and Characterization of Inhibition of Group A Streptococci by Viridans Streptococci, J Infect Dis120:698-707, 1969.
2.
Crowe, C.C.; Sanders, W.E., Jr.; and Longley, S.: Bacterial Interference. II. Role of the Normal Throat Flora in Prevention of Colonization by Group A Streptococcus, J Infect Dis128:527-532, 1973.
3.
Florey, H.W. : The Use of Microorganisms for Therapeutic Purposes , Yale J Biol Med19: 101-118, 1946.
4.
Shinefield, H.R.; Ribble, J.C.; Boris , M.; and Eichenwald , H.F.: Bacterial Interference: Its Effect on Nursery-acquired Infection with Staphylococcus aureus. I. Preliminary Observations on Artificial Colonization of Newborns, Am J Dis Child105: 646-654, 1963.
5.
Sprunt, K. and Redman, W.: Evidence Suggesting Importance of Role of Inter-bacterial Inhibition in Maintaining Balance of Normal Flora, Ann Intern Med68 :579-590, 1968.
6.
Sprunt, K.; Leidy, GA; and Redman, W.: Prevention of Bacterial Overgrowth, J Infect Dis123:1-10, 1971.
7.
Rutter, R.F. ; Ruefenacht, W.G.; Chamberlain , C.R.; Thomassen, P.R.; Rose, M.; and Scrivener, CA: The Principle of Bacterial Antagonism Applied as an Aid in the Reduction of Dental Caries , J Dent Res401:1112-1115, 1961 .
8.
Fitzgerald, R.J. and Jordan, H.V.: Polysaccharide-producing Bacteria and Caries. In: Art and Science of Dental Caries Research, Harris, R. S., Ed., New York: Academic Press, Inc., 1968, pp. 79-86.
9.
Ikeda, T.; Sandham, H.J.; and Bradley, E.L., Jr.: Changes in Streptococcus mutans and Lactobacilli in Plaque in Relation to the Initiation of Dental Caries in Negro Children, Arch Oral Biol18:555-566, 1973.
10.
Loesche, W.J. ; Rowan, J.; Straffon , L.H.; and Loos, P.J.: Association of Streptococcus mutans with Human Dental Decay, Infect Immun11:1252-1260, 1975.
11.
SCHERP, H.W.: Dental Caries: Prospects for Prevention, Science 173:1199-1205, 1971. 12. DELISLE, A.L.: Activity of Two Streptococcus mutans Bacteriocins in the Presence of Saliva, Levan, and Dextran, Infect Immunol 13:619-626,1976.
12.
Donoghue, H.D. and Tyler, J.E.: Antagonisms Among Streptococci Isolated from the Human Oral Cavity, Arch Oral Biol20: 381-388,1975.
13.
Holmberg, K. and Hallander, H.O.: Interference Between Gram-positive Microorganisms in Dental Plaque, J Dent Res51: 558-595, 1972.
14.
Miller, C.H. and Kleinman, J.L.: Effect of Microbial Interactions on in vitro Plaque Formation by Streptococcus mutans, J Dent Res53:427-434, 1974.
15.
Parker, R.B. : Paired Culture Interaction of the Oral Microbiota , J Dent Res49 :804-809,1970.
16.
Rogers, A.H.: Bacteriocin Production and Susceptibility Among Strains of Streptococcus mutans Grown in the Presence of
WEERKAMP, A.H.; VOGELS, G.D.; and SKOTNICKI, M.: Antagonistic Substances Produced by Streptococci from Human Dental Plaque and their Significance in Plaque Ecology, Caries Res 11:245-256, 1977. 19. COLEMAN, G. and WILLIAMS, R.E.O.: Taxonomy of Some Human Viridans Streptococci. In: Streptococci and Streptococcal Diseases, Wannamaker, L. W., and Matsen, J. M., Eds., New York: Academic Press, Inc., 1972, pp. 281-299.
19.
Gold, O.G.; Jordan, H.V.; and Van Houte, J.: A Selective Medium for Streptococcus mutans, Arch Oral Biol18 :1357-1364,1973.
20.
JORDAN, H.V.; KRASSE, B.; and MOLLER, A.: A Method of Sampling Human Dental Plaque for Certain "Caries-inducing" Streptococci, Arch Oral Biol 13:919-927, 1968. 22. SHKLAIR, I.L. and KEENE, H.J.: A Biochemical Scheme for the Separation of the Five Varieties of Streptococcus mutans, Arch Oral Biol 19:1079-1081, 1974.
21.
Yamamoto, T. ; Imai, S.; Nisizawa , T.; and Araya, S.: Production of and Susceptibility to Bacteriocin-like Substances in Oral Streptococci, Arch Oral Biol20:389-391, 1975.
22.
Rogers, A.H. : Effect of the Medium on Bacteriocin Production among Strains of Streptococcus mutans, Appl Micrabiol24: 294-295, 1972.
23.
Rogers, A.H. : Bacteriocin Patterns of Strains Belonging to Various Serotypes of Streptococcus mutans, Arch Oral Biol21: 243-249, 1976.
