Incubation of [14 C]-arachidonic acid with slices of inflamed human gingivae in the absence of glutathione resulted in formation of 6-keto-PGF1α, the stable hydrolytic product of prostacyclin. Significantly smaller amounts of this product were obtained when normal gingivae were treated in a similar manner. The formation of prostacyclin in inflamed gingivae may play an important role in alveolar bone resorption and as a mediator of inflammation in periodontal disease.
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