The effect of epinephrine (Epi) on the microcirculation of the pulp and its neuropharmacological mechanism has been established, as well as the existence of alpha adrenergic receptors in the blood vessels of the pulp. In addition, our results showed that local injections of Epi at doses greater than 10-8 M produced an extreme drop in intrapulpal pressure (IPP). This effect was not obtained when Epi was injected intravenously.
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