The role of cGMP as the intracellular mediator of the activation of cholinergic receptors in the secretory cells of the rat parotid gland was investigated in vitro using isolated rat parotid acinar cells. It was demonstrated that this cyclic nucleotide is involved in the intracellular translation of activation of muscarinic cholinergic receptors in these cells.
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References
1.
MangosJ.A.; N. R. McSHERRY; and S. N. ARVANITAKIS. Autonomic regulation of secretion and transductal fluxes of ions in the rat parotid. Am J Physiol225:683-688, 1973.
2.
BatzriS.; and Z. SELINGER. Enzyme secretion mediated by the epinephrine β-receptor in rat parotid slices. Factors governing efficiency of the process. J Biol Chem248:356-360, 1973.
3.
George, W.J.; J.B. Polson; A.G. O'Toole; and N.D. Goldberg.Elevation of guanosine 3', 5'cyclic phosphate in rat heart after perfusion with acetylcholine. Proc. Nat. Acad. Sci. USA66:398-403, 1970.
4.
Lee, T.P.; J.F. Kuo; and P. Greengard.Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle. Proc. Nat. Acad. Sci. USA69:3287-3291, 1972.
5.
Yamashita, K.; and J.B. Field.Elevation of cyclic guanosine 3', 5'-monophosphate levels in dog thyroid slices caused by acetylcholine and sodium fluoride. J Biol Chem247:7062-7066, 1972 .
6.
Wojcik, J.D. ; R.J. Grand; and D.V. Kimberg.Amylase secretion by rabbit parotid gland, role of cAMP and cGMP. Biochim Biophys Acta411:250-262, 1975.
7.
MangosJ.A.; N. R. McSHERRY; F. BUTCHER; K. IRWIN; and T. BARBER. Dispersed rat parotid acinar cells. I. Morphological and functional characterization. Am JPhysiol229:553-559, 1975.
8.
MangosJ.A.; N. R. McSHERRY; T. BARBER ; S. N. ARVANITAKIS;and V. WAGNER. Dispersed rat parotid acinar cells. II. Characterization of adrenergic receptors. Am J Physiol229:560-565, 1975.
9.
MangosJ.A.; N. R. McSHERRY; and T. BARBER. Dispersed rat parotid acinar cells. III. Characterization of cholinergic receptors. Am JPhysiol229:566-569, 1975.
10.
SharmaR.K.: N. K. AHMED; L. S. SUT-LIFF ; and J. S. BRUSH. Metabolic regulation of steroidogenesis in isolated adrenal cells of the rat. ACTH regulation of cGMP and cAMP levels and steroidogenesis. FEBS Letters45:107-110, 1974.
11.
LiddleG.W.; and J. G. HARDMAN. Cyclic adenosine monophosphate as a mediator of hormone action. N Engl J Med285:560-566, 1971.
