When mice were pretreated with meperidine, the incidence of lidocaine-induced
convulsions was increased. Nitrous oxide-oxygen (N2O-O2)
offered no protection against convulsions caused by lidocaine alone but lowered
the incidence of lidocaine-induced convulsions of mice pretreated with
meperidine.
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References
1.
Cluff, L.E.; Thornton, G.F.; Seidl, L.G.; and Smith, J.: Epidemiologic Study of Adverse Drug
Reactions, Trans Assoc Am Phys78:255-266,
1965.
2.
Goodson, J.M. : Personal Communication, 1977
.
3.
Smudski, J.W. ; Sprecher, R.L.; and Elliot, H.W.: Convulsive Interactions of Promethazine, Meperidine and
Lidocaine, Arch Oral Biol9:595-600,
1964.
4.
De Jong, R.H.; Heavner, J.E.; and De Oliveira , L.F.: Effects of Nitrous Oxide on the Lidocaine Seizure Threshold
and Diazepam Protection, Anesthesiology37:299-303,1972.
5.
Jerram, D.C. ; Hofman, W.F.; and Gangarosa , L.P.: Effect of Nitrous Oxide on Lidocaine Induced Convulsions in
the Dog, Fed Proc33:509, 1974.
6.
Ciarlone, A.E. , and Smudski, J.W.: Lidocaine's Influence on Brain Amines in
Mice, J Dent Res55:465-469,
1976.
7.
Ciarlone, A.E. : Influence of Convulsive Doses of Lidocaine on Central Biogenic
Amines, PhD thesis, University of
Pittsburgh .
8.
Gangarosa, L.P. ; Hofman, W.F.; Jerram, D.C.; Ciarlone, A.E.; Kling, J.M.; Hung, C.; Ross, N.M.; and Hubbard, W.: Lidocaine Anesthetic-Drug Interactions. The Third Symposium of the
Pharmacol Ther and Toxicol Group of the IADR,
3:18-35,
1976.
