The effects of obidoxime, a pyridinium oxime, on the cholinesterase activity
and acetylcholine content of the submandibular glands of rats poisoned with armin,
an organophosphorus anticholinesterase agent, were studied. The results indicate
that obidoxime-induced reactivation of phosphorylated cholinesterase can suppress
completely the increase in the concentration of acetylcholine that develops within
the submandibular gland after administration of armin alone.
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References
1.
Burgen, A.S.V., and Emmelin, N.G.: Physiology of the Salivary Glands, Edward
Arnold Ltd., London,
1961.
2.
Wills, J.H.: Pharmacological Antagonists of the Anticholinesterase Agents, in
Cholinesterases and Anticholinesterase Agents, Kolle, G.B. (ed), Springer,
Berlin, 1963.
3.
Namba, T., and Hiraki, K.: PAM (Pyridine-2-Aldoxime Methiodide) Therapy for
Alkylphosphate Poisoning , JAMA166:1834-1839, 1958
.
4.
O'Leary, J.F.; Harrison, B.; Groblewski, G.; and Wills, J.H.: The Effect of 2-Formyl-1-Methylpyridinium Iodide Oxime
(2-PAM) on Reactivation of Tissue Cholinesterase Following Poisoning by a Certain
Phosphate Anticholinesterase, Fed Proc18:430, 1959.
5.
Rothschuh, K.E. : Das herzmuskeleigene Acetylcholin.
I. Mitteilung. Freisetzung und Bestimmung-Methodik, Pfluger's
Arch258:406-414,
1954.
6.
Lewartowski, B., and Bielecki, K.: The Influence of Hemicholinium No. 3 and Vagal Stimulation on
Acetylcholine Content of Rabbit Atria, J Pharmacol Exp
Therap142:24-30,
1963.
7.
Vasic, B.V.; Milosevic, M.P.; and Terzic, M.R.: Acetylcholine Content and Cholinesterase Activity in the
Ponto-Medullary Region of Brain in Rats Treated with Armin and
Obidoxime, Biochem Pharmacol26:601-602,
1977.
8.
Riker, W.F., and Wescoe, W.C.: The Relationship Between Cholinesterase Inhibition and
Function in a Neuroeffector System, J Pharmacol Exp
Therap95:515-521,
1949.
9.
Dirnhuber, P. , and Evans, C.L.: The Effects of Anticholinesterases on Humoral Transmission in
the Submaxillary Gland, Brit J Pharmacol9:441-458,
1954.
10.
Engelhard, H. , and Erdmann, W.D.: Ein neue Reaktivator fur durch Alkylphosphat gehemmte
Acetylcholinesterase, Klin Wschr41:525-527,
1963.
11.
Erdmann, W.D. , and Engelhard, H.: Pharmakologische-toxikologische Untersuchungen mit dem
Dichlorid des Bis-4-hydroxyiminomethyl- pyridinium-(1)-methyl- athers, einen neuen
Esterase-Reaktivator, Arzneim Forsch14:5 -11,
1964.
12.
Bisa, K.; Muller, 0.; Fishcher, G.; Oldiges, H.; and Zoch, E.: Die Antidotwirkung von
Bis-4-hydroxyiminomethylpyridinium-(1)- methyl-ather-dichlorid bei mit
Alkylphosphat vergifteten Ratten, Arzneim Forsch14:85-88,
1964.
13.
Kuhnen-Clausen, D.: Structure-Activity Relationship of Mono- and Bisquaternary
Pyridines in Regard to Their Parasympatholytic Effects,
Toxicol Appl Pharmacol23:443-454,
1972.
14.
Terzic, M., and Milosevic, M.: Antimuscarinic Properties of Trimedoxime and Obidoxime,
Abstracts, Sixth International Congress of
Pharmacology, Helsinki,
1975. 15. Pepeu, G.: Effect of Tremorine and Some Anti-Parkinson's Disease Drugs
on Acetylcholine in the Rat Brain , Nature 200:895,
1963.
15.
Holmstedt, B.: Mobilization of Acetylcholine by Cholinergic
Agents, Ann NY Acad Sci144:433-453,
1967.
16.
Wills, J.H. ; Kunkel, A.M.; Brown, R.V.; and Groblewski , G.E.: Pyridine-2-aldoxime Methiodide and Poisoning by
Anticholinesterases, Science125:743, 1957.
