Rat oral mucosa microsomal Δ 4-3-ketosteroid-5α-A-ring reductase enzyme system, reducing testosterone and 4-androstenedione, was found to be inducible by systemic administration of medroxyprogesterone acetate (MPA). MPA, when used in a mixture with testosterone and/ or 4-androstenedione in vitro, acted as a competitive inhibitor of the reduction of these substrates.
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