Restricted accessResearch articleFirst published online 1978-03
BASIC BIOLOGICAL SCIENCES Confirmation that Neither Phenotype Nor Hydroxylation of Collagen Is Altered In Overgrown Gingiva From Diphenylhydantoin-Treated Patients
Collagens, solubilized by pepsin-digestion of diphenylhydantoin-induced overgrown gingiva, appeared similar to collagens solubilized from inflamed gingiva with regard to: ratio of type I to type III collagen, ratio of α1 to α2 of type I collagen, and degree of hydroxylation of type I collagen.
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References
1.
Angelopoulos, A.P.: Diphenylhydantoin Gingival Hyperplasia: A Clinical Review. I. Incidence, Clinical Features and Histopathology, J Canad Dent Assn41:103-106, 1975.
2.
Hassell, T.M. ; Page, R.C.; Narayanan , A.S.; and Cooper , C.G.: Diphenylhydantoin (Dilantin) Gingival Hyperplasia: Drug-Induced Abnormality of Connective Tissue , Proc Nat Acad Sci USA, 73:2909-2912, 1976 .
3.
Kasai, S., and Hachimine, K.: Effect of 5,5-Diphenylhydantoin Sodium on the Synthesis of Collagen by Some Fibroblastic Cell Lines Including Gingiva Derived Cells, Bull Tokyo Dent Coll15:53-62, 1974.
4.
Rose, G.G., and Robertson, P.B.: Collagenolysis by Human Gingival Fibroblast Cell Lines, J Dent Res56:416-424, 1977.
5.
Liu, T.Z. , and Bhatnagar, R.S.: Inhibition of Protocollagen Proline Hydroxylase by Dilantin, Proc Soc Exp Biol Med142:253-255, 1973.
6.
Blumenkratz, N., and Asboe-Hansfn , G.: Effect of Diphenylhydantoin on Connective Tissue, Acta Neurol Scand50:302-306, 1974.
7.
Ballard, J.B. , and Butler, W.T.: Proteins of the Periodontium. Biochemical Studies on the Collagen and Noncollagenous Proteins of Human Gingivae , J Oral Pathol3:176-184, 1974.
8.
Miller, E.J. : Structural Studies on Cartilage Collagen Employing Limited Cleavage and Solubilization with Pepsin, Biochemistry11:4903-4909, 1972.
9.
Grant, R.A.: Estimation of Hydroxyproline by the Autoanalyzer, J Clin Pathol17 :685-686, 1964.
10.
Chung, E., and Miller, E.J.: Collagen Polymorphism: Characterization of Molecules with the Chain Composition [α1 (III)]3 in Human Tissues, Science183:1200-1201, 1975.
11.
Bailey, A.J. , and Robins, S.P.: Current Topics in the Biosynthesis, Structure and Function of Collagen, Sci Prog Oxf63 :419-444, 1976.
12.
Epstein, E.H. , Jr.; Scott, R.D.; Miller , E.J.; and Piez, K.A.: Isolation and Characterization of the Peptides Derived from Soluble Human and Baboon Skin Collagen after Cyanogen Bromide Cleavage, J Biol Chem246:1718-1724, 1971 .