Incisors of Mg-deficient rats showed a marked inhibition of eruption and a decrease in mitoses of apical tissues. Cortisone administration resulted in some increase in eruption rate and cell division though these remained below the values of Mg-supplemented controls. An improvement in gross condition and a less severe histopathology of incisor tissues were also observed in cortisone-treated rats.
Get full access to this article
View all access options for this article.
References
1.
Domm, L.V., and Marzano, R.: Observations on the Effects of Certain Hormones on the Growth Rate of the Incisor of the Albino Rat, abstract, Anat Rec118 :383, 1954.
2.
Garren, L., and Creep, R. 0.: Effect of Adrenal Cortical Hormones on Eruption Rate of Incisor Teeth in the Rat, Endocrinol66:625-628, 1960.
3.
Domm, L.V., and Wellband, W.A.: Effects of Adrenalectomy, Thyroidectomy, Thyro-adrenalectomy and Cortisone on Eruption Rate of Incisors in Adult Female Rats, Proc Soc Exp Biol Med107:268-272, 1961.
4.
Farmer, L.G. ; Katonah, F.; and Angrist, A.A.: Comparative Effects of ACTH, Cortisone, Corticosterone, Desoxycorticosterone, Pregnenolone on Growth and Development of Infant Rats, Proc Soc Exp Biol Med77:215-218, 1951.
5.
Leroy, P., and Domm, L.V.: Eruption Precoce des Incisives Superieures et Inferieures des Jeunes Rats Traites a la Cortisone, Ann Endocrinol16:773-784, 1955.
6.
Goldsmith, E.D. , and Ross, L.: A Histochemical and Histological Study of the Effects of Cortisone on the Lower Incisors of Fetal and Postnatal Rats , Acta Endocrinol22:23-41, 1956.
7.
Wellband, W.A. , and Domm, L.V.: Effect of Cortisone, Amputation and Food Restriction on Growth of Rat Maxillary Incisors. Proc Soc Exp Biol Med116:718-720, 1964.
8.
Domm, L.V., and Kiely, M.L.: The Effect of Cortisone on Mitotic Activity in the Rat Incisor, Proc Soc Exp Biol Med129:912-916, 1968.
9.
Kiely, M.L., and Domm, L.V.: Circadian Uptake of 'H-thymidine in the Rat Incisor Under the Influence of Cortisone, Proc Soc Exp Biol Med143:844-849, 1973.
10.
Aikawa, J.K.: The Role of Magnesium in Biologic Processes, 1st ed, Springfield : Charles C Thomas, 1963, pp 49-51.
11.
Aikawa, J.K.: The Relationship of Magnesium to Disease in Domestic Animals and in Humans , 1sted, Springfield: Charles C Thomas, 1971 , pp 10-36.
12.
Wacker, W.E.C. : The Biochemistry of Magnesium, Ann NY Acad Sci162:717-726, 1969.
13.
Trowbridge, H. O., and Jenks, P.: Magnesium Deficiency, J Calif Dent Assoc44:444-448, 1968.
14.
Gagnon, J.; Schour, I.; and Patras, M.C.: Effect of Magnesium Deficiency on Dentin Apposition and Eruption in Incisor of Rat, Proc Soc Exp Biol Med49:662-666, 1942.
15.
Kusner, W.; Michaeli, Y.; and Weinreb, M.M.: Role of Attrition and Occlusal Contact in the Physiology of the Rat Incisor: VI. Impeded and Unimpeded Eruption in Hypophysectomized and Magnesium-Deficient Rats, J Dent Res52 :65-73, 1973.
16.
Klein, H.; Orent, E.R. ; and Mccollum, E.V. : The Effects of Magnesium Deficiency on the Teeth and Their Supporting Structures in Rats, Am J Physiol112:256-262, 1935.
17.
Becks, H., and Furuta, W.J.: Effect of Magnesium Deficient Diets on Oral and Dental TissuesI. Changes in the Enamel Epithelium, JADA26:883-891, 1939.
18.
Becks, H., and Furuta, W.J.: Effect of Magnesium Deficient Diets on Oral and Dental Tissues II. Changes in the Enamel Structure, JADA28:1083-1088, 1941.
19.
Becks, H., and Furuta, W.J.: The Effect of Magnesium-Deficient Diets on Oral and Dental Structures III. Changes in the Dentine and Pulp Tissue, Am J Ortho Oral Surg28(oral surg):1-14, 1942.
20.
Weinreb, M.M. ; Kusner, W. ; and Michaeli, Y.: Role of Attrition and Occlusal Contact in the Physiology of the Rat Incisor: VII. Formation of Impeded and Unimpeded Incisors in Magnesium-Deficient Rats, J Dent Res52:498-507, 1973.
21.
Heggtveit, H.A.; Herman, L.; and Mishra, R.K.: Cardiac Necrosis and Calcification in Experimental Magnesium Deficiency. A Light and Electron Microscopic Study, Am J Path45 :757-782, 1964.
22.
Baume, L.J. ; Becks, H.; and Evans, H.M.: Hormonal Control of Tooth Eruption. I. The Effect of Thyroidectomy on the Upper Rat Incisor and the Response to Growth Hormone, Thyroxin, or the Combination of Both, J Dent Res33:80-90, 1954.
23.
Kruse, H.D. ; Orent, E.R.; and Mccollum , E.V.: Studies on Magnesium Deficiency in Animals I. Symptomatology Resulting From Magnesium Deprivation , J Biol Chem96:519-539, 1932.
24.
Greenberg, D.M., and Tufts, E.V.: The Nature of Magnesium Tetany , Am J Physiol121:416-423, 1938.
25.
Farnell, D.R. : Cortisone Treatment in Magnesium Deficiency of Rats, Am J Vet Res27:415-418, 1966.
26.
Aikawa, J.K. ; Harms, D.R.; and Reardon, J.Z.: Effect of Cortisone on Magnesium Metabolism in the Rabbit, Am J Physiol199:229-230, 1960.
27.
Duckworth, J.; Godden, W.; and Warnock, G.M.: The Effect of Acute Magnesium Deficiency on Bone Formation in Rats, Biochem J34:97-108, 1940.
28.
Hunt, B.J.: Age and Magnesium Deficiency in the Rat with Emphasis on Bone and Muscle Magnesium , Am J Physiol221:1809-1817, 1971 .
29.
Ness, A.R., and Smale, D.E.: The Distribution of Mitoses and Cells in the Tissues Bounded by the Socket Wall of the Rabbit Mandibular Incisor, Proc Roy Soc B151:106-128, 1959.
30.
Michaeli, Y. ; Weinreb, M.M.; and Zajicek, G.: Role of Attrition and Occlusal Contact in the Physiology of Rat Incisors: V. Life Cycle of Inner Enamel Epithelial Cells at Various Rates of Eruption, J Dent Res51:960-963, 1972.
31.
Greenberg, D.M.; Lucia, S.P.; and Tufts, E.V.: The Effect of Magnesium Deprivation on Renal Function, Am J Physiol121:424-430, 1938.
32.
Barron, G.P. ; Brown, S.O.; and Pearson, P.B.: Histological Manifestations of a Magnesium Deficiency in the Rat and Rabbit, Proc Soc Exp Biol Med70:220-223, 1949.
33.
Bernick, S. , and Hungerford, G.F.: Effect of Dietary Magnesium Deficiency on the Bones and Teeth of Rats, J Dent Res44:1317-1324, 1965.
34.
Hunt, B.J., and Belanger, L.F.: Localized, Multiform, Sub-Periosteal Hyperplasia and Generalized Osteo-Myelosclerosis in Magnesium-Deficient Rats, Calcif Tiss Res9:17-27, 1972.
35.
Heggtveit, H.A.: Myopathy in Experimental Magnesium Deficiency , Ann NY Acad Sci162:758-765, 1969.
36.
Artizyu, N. , and Messier, B.: Histological Changes in the Gastric Mucosa of Magnesium Deficient Rats, Brit J Exp Path52:70-74, 1971.
37.
Alcock, N.W. ; Shils, M.E.; Lieberman , P.H.; and Erlandson , R.A.: Thymic Changes in the Magnesium-Depleted Rat, Cancer Res33:2196-2204, 1973.
