Incorporation of tetracycline into dental enamel was studied by exposing presoftened enamel slabs to tetracycline-containing mineralizing solutions. Tetracycline was incorporated only when remineralization (assessed by hardness) occurred and the experimental conditions favored the formation of a soluble tetracycline-Ca complex. The fluorescence induced by tetracycline incorporation into the enamel slabs was comparable to that reported under in vivo conditions.
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References
1.
Shwachman, H. ; Fekete, E.; Kulczyski , L.L.; and Foley, G.E.: The Effect of Long-Term Antibiotic Therapy in Patients with Cystic Fibrosis of the Pancreas , Antibiot Ann692-699, 1958-59.
2.
Zegarelli, E.V. ; Kutscher, A.H.; Denning , C.R.; Fahn, B.S.; Botwick , J.; and Corwin, R.A.: Discoloration of the Teeth in Patients with Cystic Fibrosis of the Pancreas: Affected Teeth and Intensity of Discoloration , Quart Nat DA23:15-16, 1964.
3.
Sullivan, R.E. : Discoloration of the Teeth in Patients with Cystic Fibrosis, Indianap Dist D Soc18:10-12, 1964.
4.
Swallow, J.N. ; DE Haller, J.; and Young, W.F.: Side Effect to Antibiotics in Cystic Fibrosis : Dental Changes in Relation to Antibiotic Administration, Arch Dis Child42:311-318, 1967.
5.
Wallman, I.S. , and Hilton, H.B.: Teeth Pigmented by Tetracycline , Lancet1:827-829, 1962.
6.
Ibsen, K.H.; Urist, M.R.; and Sognnafs, R.F.: Differences Among Tetracyclines with Respect to the Staining of Teeth , J Pediatr67:459-462, 1965.
7.
Milch, R.A.; Rall, D.P.; and Tobie, J.E.: Bone Localization of the Tetracyclines, J Nat Cancer Inst19:87-93, 1957.
8.
Davies, P.A. ; Little, K.; and Aherne, W.: Tetracyclines and Yellow Teeth, Lancet1:734, 1962.
9.
Harcourt, J.K. ; Johnson, N.W.; and Storey, E.: In Vivo Incorporation of Tetracycline in the Teeth of Man, Arch Oral Biol7:431-437, 1962.
10.
Porteous, J.R. , and Weyman, J.: Tetracyclines and Yellow Teeth , Lancet1:862, 1962.
11.
Urist, M.R. , and Ibsen, K.H.: Chemical Reactivity of Mineralized Tissue with Oxytetracycline, Arch Pathol76:484-496, 1963.
12.
Ibsen, K.H. , and Urist, M.R.: The Biochemistry and the Physiology of the Tetracyclines : With Special Reference to Mineralized Tissues, Clin Orthop32:143-169, 1964.
13.
Hennon, D.K. : Dental Aspects of Tetracycline Therapy: Literature Review and Results of a Prevalence Survey, J Ind St D Assn44:484-492, 1965.
14.
Weyman, J.: Tetracyclines and the Teeth, Practitioner195:661-665, 1965.
15.
Zussman, W.V. : Tetracycline Incorporation at the Growing End of the Rat Incisor, Arch Oral Biol12:911-912, 1967.
16.
Stewart, D.J. : Tetracyclines: Their Prevalence In Children's Teeth, Brit Dent J124:318-320, 1968.
17.
Shwachman, H.: and SCHUSTER, A.: The Tetracyclines: Applied Pharmacology, Pediatr Clin North Amer3:295-303. 1956.
18.
Johnson, R.H. , and Mitchell, D.F.: The Effects of Tetracyclines on Teeth and Bones, J Dent Res45:86-93, 1966.
Pigman, W., and Newburn, E.: Evaluation of Anticaries Agent by the Use of the Artificial Mouth , J Dent Res41:1304-1311, 1962 .
21.
Koulourides, T.: Remineralization of Enamel and Dentine, Dent Clin North Amer1962, p 485.
22.
Keil, A., and Ferk, H.: Untersuchungen zur Tetrazyklinverfarbung wachsender Zähne und Kiefer , Wien Tier Monats50:350-357, 1963.
23.
Neuman, W.F. , and Neuman, M.W.: The Chemical Dynamics of Bone Mineral , Chicago and London: The University of Chicago Press , 1958, p 34.
24.
Hamp, S.E.: The Tetracyclines and Their Effect on Teeth, Särtryck ur Odontologisk Tidskrift75:33-49, 1967
25.
Eger, W.; Kämmer, H.; and Bothman, G.: Experimentelle Beitrage zur Tetrazyklinablagerung in den Zahnen, Deutche Zähnarzliche Zeitschr20:328, 1965. Cited by Hamp (Ref. 24).
26.
Mitchell, D.F. , and Fahmy, H.: A Test of Seven Agents for Total Dye and Intrinsic Dental Staining Activity, J Oral Ther and Pharm4:378-381, 1968.
27.
Wisotzky, J. : Effect of Tetracycline on the Phosphorescence of Teeth, J Dent Res51 :7-11, 1972.
28.
Ibsen, K.H. , and Urist, M.R.: Complexes of Calcium and Magnesium with Oxytetracycline, Proc Soc Exper Biol Med109:797-801, 1962.
