Mouse brain was analyzed for serotonin, norepinephrine, and dopamine. Pargyline plus lidocaine treatment caused an increased accumulation rate of serotonin over one hour compared to pargyline controls. α Methyl-p-tyrosine plus lidocaine treatment caused a decreased depletion rate of dopamine over four hours compared to rates of α methyl-p-tyrosine controls, and no difference for norepinephrine.
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References
1.
Azzaro, A.J.; Wenger, G.R.; Craig, C.R.; and Stitzel, R.E.: Reserpine-Induced Alterations in Brain Amines and Their Relationship to Changes in the Incidence of Minimal Electroshock Seizures in Mice, J Pharmacol Exp Ther180:558-562, 1972.
2.
De LATorre, J.C., and Mullan, S.A.: A Possible Role for 5-Hydroxytryptamine in Drug Induced Seizures, J Pharm Pharmacol22:853-859, 1970.
3.
Gray, W.D., and Rauh, C.E.: The Relationship Between Monoamines in Brain and the Anticonvulsant Action of Inhibitors of Carbonic Anhydrase, J Pharmacol Exp Ther117:206-218, 1971.
4.
De Jong, R.H., and Walts, L.F.: Lidocaine Induced Psychomotor Seizures in Man, Acta Anesth Scand Suppl23:598-604, 1966.
5.
Smudski, J.W.: Electroencephalographic and Behavioral Responses to Some Drugs Injected Directly into Specific Brain Areas of the Rabbit, Ph.D. Thesis, University of California, San Francisco, 1965.
6.
Wagman, I.H. ; DE Jong, R.H.; and Prince, D.A.: Effects of Lidocaine on Spontaneous Cortical and Subcortical Electrical Activity. Arch Neurol18:277-290, 1968.
7.
Aldrete, J.A. , and Daniel, W.: Evaluation of Premedicants as Protective Agents Against Convulsive (LD50) Doses of Local Anesthetic Agents in Cats , Anesth Anal (Cleve) 50:127-130, 1971.
8.
De Jong, R.H. , and Heavner , J.E.: Diazepam Prevents Local Anesthetic Seizures , Anesthesiology34:523-531, 1971.
9.
De Jong, R.H. ; Heavner, J.E.; and De Oliveira , L.F.: Nitrous Oxide Elevates Local Anesthetic Seizure Threshold, Exp Neurol35:558-564,1972.
10.
Ciarlone, A.E. , and Smudski, J.W. : Lidocaine's Influence on Brain Amines in Mice, J Dent Res55: 465-469, 1976.
11.
Corrodi, H. ; Fuxe, K.; Lidbrink , P. ; and Olson, L.: Minor Tranquilizers, Stress and Central Catecholamine Neurons, Brain Research29:1-16, 1971.
12.
Neff, N.H.; Spano, P.F.; Groppetti, A.; Wang, C.T.; and Costa, E.: A Simple Procedure for Calculating the Synthesis Rate of Norepinephrine , Dopamine, and Serotonin in Rat Brain, J Pharmacol Exp Ther176 :701-710, 1971.
13.
Maickel, R.P. ; Cox, R.H. JR. ; Saillant , J.; and Miller, F.P.: A Method for the Determination of Serotonin and Norepinephrine in Discrete Areas of Rat Brain, Int J Neuro-pharmacol7:275-281, 1968.
14.
Chang, C.C. : A Sensitive Method for Spectrophotofluorometric Assay of Catecholamines, Int J Neuropharm3:643-649, 1964.
15.
Neff, N.H., and Tozer, T.N.: In Vivo Measurement of Brain Serotonin Turnover. In Garattini, S., and Shore, P.A.(eds): Advances in Pharmacology, Vol. 6A, New York: Academic Press, 1968, p 67.
16.
Goldstein, A. : Biostatistics: An Introductory Text, New York: Macmillan Co., 1964, p 144.
17.
Costa, E., and Meek, J.L.: Regulation of Biosynthesis of Catecholamines and Serotonin in the CNS, Ann Rev Pharmacol14 :491-511, 1974.
