Chlorhexidine and Fluoride in Prevention of Plaque and Caries in Hamsters

Abstract

The effect of combined administration of chlorhexidine and fluoride in the drinking water of hamsters on plaque and caries prevention was studied. Plaque indices of the hamsters receiving chlorhexidine either alone or simultaneously with fluoride were significantly lower than those of the control and fluoride only treated hamsters. The type of plaque indices used in this investigation was area scores. The necessity of quantitatively assessing plaque by several parameters was emphasized. The degrees of caries of the experimental groups were significantly lower than of the control group during the cariogenic diet regime. The anti-cariogenic effect of chlorhexidine and fluoride at low concentrations each provided simultaneously with a cariogenic diet, was confirmed. The differences in caries rate between the experimental groups were not significant. No additive effect on the cariostatic action of chlorhexidine and fluoride was observed when both reagents were applied simultaneously due probably to the low F concentration in the drinking water. The results did not show a direct quantitative relationship between plaque and caries.

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References

Regolati, B. ; Schmid, R. ; and Mühle-Mann , H.R. : Combination of Chlorhexidine and Fluoride in Caries Prevention, An Animal Experiment, Helv Odontol Acta 18 : 12-16, 1974.

Gron, P. : Chemistry of Topical Fluorides, Workshop on Cariostatic Mechanisms of Fluoride , Caries Res, In Press, 1976.

Gedalia, I. : Workshop on Cariostatic Mechanisms of Fluoride, Discussion: Systemic and Topical Fluorides, Caries Res, In Press, 1976.

Davies, R.M. , and Hull, P.S. : Plaque Inhibition and Distribution of Chlorhexidine in Beagle Dogs, J Period Res 8: Suppl. 12: 22-27, 1973.

Kornman, K.S. ; Clark, W.B. ; Kreitzman , S.N. ; and Alvarez, C. : Caries Control in the Albino Rat with Chlorhexidine Gluconate (Hibitane), Arch Oral Biol 18 :165-170, 1973.

Larson, R.H. : Animal Studies Relating to Caries Inhibition by Fluoride, Workshop on Cariostatic Mechanisms of Fluorides, Caries Res, In Press, 1976.

Fuks, A. ; Anaise, J. ; Westreich, V. ; and Gedalia, I. : Effect of Fluoride Supplementation of a Citrus Beverage on the Erosion Rate of Molars of Hamsters, J Dent Res 52: 1149,1973.

Keyes, P.H. : A Method of Recording and Scoring Gross Carious Lesions in the Molar Teeth of Syrian Hamsters, J Dent Res 23: 439-444, 1944.

Gabriel, K.R. : A Procedure for Testing the Hemogeneity of all Sets of Means in Analysis of Variance, Biometrics 20:459-477, 1964.

10.

Gedalia, I. ; Anaise, J. ; Westreich . V. ; and Fuks, A. : Predisposition to Caries in Hamsters Following the Erosive Effect of a Commercial Citrus Beverage Administered With and Without Supplemental Fluoride, J Dent Res 54:496-499, 1975.

11.

Park, K.L. , and Katz, S. : In Vivo Plaque Measurement in the Rat. J Dent Res 53: 1346-1350, 1974.

12.

Luoma, H. ; Ainamom, J. ; Soderholm, S. ; Meurman, J. ; and Helminen, S. : Reduction of Enamel Solubility and Plaque Development with Chlorhexidine-Fluoride Solutions, Scand J Dent Res 81:523-527, 1973.

13.

Loe, H. : Chlorhexidine in the Prophylaxis of of Dental Diseases, J Period Res 8: Suppl. 12:5-6, 1973.

14.

Gaffar, A. ; Marcussen, H.W. ; Kestenbaum, R.C. ; and King, W.Y. : Effects of Chlorhexidine-Dihydrochloride in the Diet on Caries in Hamsters , IADR Abstracts, No 143, 1973.

15.

Silverstone, L.M. : Remineralization Phenomena, Workshop on Cariostatic Mechanisms of Fluorides, Caries Res, In Press, 1976.

16.

Luoma, H. : The Effects of Chlorhexidine and Fluoride Combinations of the Potassium, Sodium and Phosphorus Content and Acid Production of Cariogenic Streptococci , Arch Oral Biol 17:1431-1437, 1972 .