Two-hundred and fourteen subjects ranging in age from 22 to 63 years used either a mouthwash that contained 0.035% w/v alexidine· 2HCl (2-ethylhexyl bisbiguanidine dihydrochloride) or a placebo twice daily on a double-blind basis for six months in conjunction with routine oral hygiene procedures. The results indicated that alexidine·2HCl was safe and was statistically more effective in producing a clinically significant reduction in gingivitis than was the placebo.
Get full access to this article
View all access options for this article.
References
1.
Carlson, H.C. , and Porter, C.K.: Inhibitory Effect of a Synthetic Antibiotic Mouthwash (QR-711) on Dental Plaque and Gingivitis in Young Adults , J Periodont44 : 225-227, 1973.
2.
Lobene, R.R. , and Soparkar, P.M.: The Effect of an Alexidine Mouthwash on Human Plaque and Gingivitis, JADA87:848-851, 1973.
3.
Peterson, J.K., and Casad, R.J.: Effects of an Anti-Bacterial Mouthrinse on Gingivitis and Dental Plaque , abstracted, IADR Program and Abstracts of Papers, No. 824, p 258, 1972 .
4.
Spolsky, V.W. ; Bhatia, H.L. ; Forsythe, A.; and Levin, D.: The Effect of an Antimicrobial Mouthwash on Dental Plaque and Gingivitis in Young Adults , J Periodont46: 685-690, 1975.
5.
Ramfjord, S.P. : The Periodontal Disease Index (PDI), J Periodont38:602-610, 1967.
6.
Suomi, J.D.; Horowitz, H.S.; Barbano, J.P.; Spolsky, V.W.; and Heifetz, S.B.: A Clinical Trial of a Calculus-Inhibitory Dentifrice, J Periodont45: 139-145, 1974.
7.
Quigley, G., and Hein, J.: Comparative Cleansing Efficiency of Manual and Power Brushing, JADA65:26-29, 1962.
8.
Schour, I., and Massler, M.: Gingival Disease in Postwar Italy. I. Prevalence of Gingivitis in Various Age Groups, JADA35: 475-482, 1947.
9.
Podshadley, A.G., and Haley, J.V.: A Method for Evaluating Oral Hygiene Performance , Pub Health Reports83:259-264, 1968.
10.
Dixon, W.J. (ed): BMDP-Biomedical Computer Programs, Berkeley: University of California Press, 1975.
11.
Dixon, W.J., and Massey, F.J. JR.: Introduction to Statistical Analysis (3rd ed) New York: McGraw-Hill Book Co., 1969.
12.
Brady, J.M. ; Gross, A.; Grower , M.F.; Carter, H.G.; and Barnes, G.P.: Dental Plaque Reduction with an Anti-Bacterial Mouthrinse-Ultrastructural, Microbiological and Biochemical Changes, J Prev Dent2: 10-19, 1975.
13.
Flotra, L. ; Gjermo, P.; Rolla, G. ; and Waerhaug, J.: Side Effects of Chlorhexidine Mouth Washes, Scan J Dent Res79 :119-125, 1971.
