When highly controlled parallel rat caries studies were run simultaneously in six laboratories, a similar pattern of caries developed in every laboratory with a range in mean values such that the results of no investigator were significantly different from those of at least two others. These results indicate that the major factors influencing development of rat caries have been recognized and can be controlled within reasonable limits.
Get full access to this article
View all access options for this article.
References
1.
Mccollum, E.V.; Simmonds, N.; Kinney, E.M.; and Grieves, C.J.: The Relation of Nutrition to Tooth Development and Tooth Preservation. I. A Preliminary Study of Gross Maxillary and Dental Defects in Two Hundred and Twenty Rats on Defective and Deficient Diets, Johns Hopkins Hosp Bull33:202-215, 1922.
2.
Grieves, C.J.: A Preliminary Study of Gross Maxillary and Dental Defects in Three Hundred Rats on Defective and Deficient Diet, J Nat Dent Assoc9:467-497, 1922.
3.
Van Reen, R., and Cotton, W.R.: Methods for Scoring Dental Caries in Experimental Animals, in Art and Science of Dental Caries ResearchR. S. Harris (ed.) , New York, Academic Press, 1968, pp 277-315.
4.
Wynn, W.; Haldi, J.; Shaw, J.H.; and Sognnaes, R.F.: Difference in the Caries-Producing Effects of Two Purified Diets Containing the Same Amount of Sugar, J Nut R50:267-274, 1953.
5.
Mcclure, F.J. and Losee, F.L.: Dental Caries and Rate of Growth in Three Strains of White Rats, Abst. 110. J Dent Res34:712, 1955.
6.
Konig, K.G.; Larson, R.H.; Fitzgerald, R.J.; and Muhlemann, H.R.: Caries Activity of Male and Female Osborne-Mendel Rats in Different Environments , Helv Odont Acta9:115-119, 1965.
7.
Keyes, P.H.: The Infectious and Transmissible Nature of Experimental Dental Caries Findings and Implications, Arch Oral Biol1, 304-320, 1960.
8.
Larson, R.H.; Keyes, P.H.; and Goss, B.J.: Development of Caries in the Hunt-Hoppert Rats Under Different Experimental Conditions, J Dent Res47:704-709, 1968.
9.
Navia, J.M.; Lopez, H.; and Harris, R.S.: Purified Diet for Dental Caries Research with Rats, J Nutr97:133-140, 1969.
10.
Keyes, P.H. : Dental Caries in the Molar Teeth of Rats. II. A Method for Diagnosing and Scoring Several Types of Lesions Simultaneously , J Dent Res37:1088-1099, 1958 .
11.
Scheffe, H.: The Analyses of Variance, Wiley and Sons, Inc. , New York, pp 109-110, 1953.
