The cytotoxic potential of four alloy materials was tested; three were Ni-Cr based alloys and one was a Fe-Cr based alloy. Adverse cellular changes were not found in tissue culture studies of castings of the alloys. Cultures containing Ni-Cr powders did show prominent zones of lysis and cell alteration. The cytologic potential of products obtained from surfaces of casting alloys may offer means for estimating long-term clinical toxicity.
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