The following drugs have been demonstrated to be secreted by the parotid glands of rats and human beings: amobarbital, chlorpromazine, codeine, glutethimide, meprobamate, pentobarbital, phenobarbital, and secobarbital. Methadone could not be detected in the parotid saliva of either rats or human beings, and morphine has been demonstrated only in parotid saliva of rats.
Get full access to this article
View all access options for this article.
References
1.
Munch, J.C.: Saliva Tests; III, Detecting the Administration of Some Opium Derivatives to Horses, J Am Pharm Assoc24 :557-560, 1935.
2.
Iribe, K.; Miyazzawa, K.; Nakajima, H.; and Kamoshita, E.: Concentration Correlation Between the Blood and Saliva Alcohol Levels Following Alcoholic Consumption, J Nihon Univ Sch Dent11:34-39, 1969.
3.
Borzelleca, J.F., and Cherrick , H.M.: The Excretion of Drugs in the Saliva: Antibiotics, J Oral Ther2:180-187, 1965.
4.
Rasmussen, F. : Salivary Excretion of Sulfonamides and Barbiturates by Cows and Goats, Acta Pharmacol Toxicol ( Kbh) 21: 11-19, 1964.
5.
Piraino, A.J. ; DI Gregorio, G.J.; and Nagle, B.T.: Excretion of Barbiturates into Induced Parotid Saliva of the Rat, J Dent Res55:43-47, 1976.
6.
Bender, I.B. ; Pressman, R.S.; and Tash-Man , S.G.: Studies on Excretion of Antibiotics in Human SalivaI. Pencillin and Streptomycin, JADA46:164-170, 1953.
7.
Conrad, G.J. ; Jeffay, H.; Boshes , L.; and Steinberg, A.D.: Levels of 5,5-Diphenylhydantoin and Its Major Metabolite in Human Serum, Saliva, and Hyperplastic Gingiva, J Dent Res53: 1323-1329, 1974.
8.
Koysooko, R. ; Ellis, E.F.; and Levy, G.: Relationship Between Theophylline Concentration in Plasma and Saliva of Man, Clin Pharmacol Therap15:454-460. 1974.
9.
Chernick, W.S. ; Bobyock, E.; and Di Gregorio , G.J.: Collection and Quantitation of Mouse Salivary Secretions, J Dent Res50:165, 1971.
10.
Eichel, H.J. ; Conger, N.; and Chernick, W.S.: Acid and Alkaline Ribonucleases of Human Parotid, Submaxillary, and Whole Saliva, Arch Biochem Biophysic107 :197-208, 1964.
11.
Carlson, A.J. , and Crittenden, A.L.: The Relation of Ptyalin Concentration to the Diet and to the Rate of Secretion of the Saliva, Am J Physiol26:169-177, 1910.
12.
Curby, W.A.: Device for Collection of Human Parotid Saliva, J Lab Clin Med41: 493-496, 1953.
13.
Fish, F., and Wilson, W.D.C.: Gas Chromatographic Determination of Morphine and Cocaine in Urine . J Chromatogr40:164-168,1969.
14.
Schneyer, L.H.; and Schneyer, C.A.: Inorganic Composition of Saliva, in Handbook of Physiology, Section 6, Vol 11, Secretion, Washington, DC: American Physiological Society, 1967, p. 523.
15.
Maynert, E.W.: Nonbarbiturate Sedatives and Hypnotics, in: Drill's Pharmacology in Medicine , 4th ed, New York: McGraw Hill, 1971, p. 238
16.
, Domino, E.F.: Antipsychotics: Phenothiazines, Thioxanthenes, Butyrophenones and Rauwolfia Alkaloids, in: Drill's Pharmacology in Medicine, 4th ed, New York: McGraw Hill, 1971, p 474.
