Hamsters were used to determine the effect of calcium glycerophosphate on dental caries. Within the 60-day experimental period, calcium glyceroPhosPhate significantly reduced caries when fed in the diet at levels of 1% and higher, and when applied topically at levels of 2% and higher.
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References
1.
Osborn, T.W.B. ; Noriskin, J.N.; and Staz, J.: Inhibition In Vitro of Decalcification in Teeth, J Dent Res16: 545-550, 1937.
2.
Osborn, T.W.B. : Further Studies on the In Vitro Decalcification of Teeth, J Dent Res20: 59-69, 1941.
3.
Regolati, B. , and Hotz, P.: Cariostatic Effect of Glycerophosphate, Helv Odont Acta16: 13-18, 1972.
4.
Grenby, T.H. : Trials of Three Organic Phosphorus-Containing Compounds as Protective Agents Against Dental Caries in Rats, J Dent Res52: 454-461, 1973.
5.
Bowen, W.H.: The Cariostatic Effect of Calcium Glycerophosphate in Monkeys, Caries Res6: 43-51, 1972.
6.
Plathner, C.P. , and Winiker, M.: Animal Experiments on the Caries Reducing Effect of Glycerophosphate, abstracted, Caries Res5: 7, 1971.
7.
Keyes, P.H.: Evaluation of Two Topical Application Methods Used to Assess the Anti-Dental Caries Potential of Drugs in Hamsters, J Oral Ther2: 285, 1966.
8.
Englander, H.R. , and Keyes, P.H.: Effect of Phosphate Supplements on Cavitation in Hamsters Infected with Caries-Conducive Streptococci, J Dent Res49: 140-144, 1970.
9.
Keyes, P.H.: Odontopathic Infections, in Hoffman, R.A. (ed) : The Golden Hamster, 1st ed, Ames, Iowa: The Iowa State University Press, 1968, p 253, chap 19.
10.
Harris, R.S.: Minerals: Calcium and Phosphorus, in Gould, R.F. (ed) : Dietary Chemicals Versus Dental Caries, Washington, DC: American Chemical Society, 1970, pp 116-122.
11.
Navia, J.M. : Prevention of Dental Caries: Agents Which Increase Tooth Resistance to Dental Caries, Int Dent J22: 427-440, 1972.
12.
Ostrom, C.A. , and Van Reen, R.: Systemic Phosphate Influences on Dental Caries in the NMRI-D Rat, J Dent Res42: 732-738, 1963.
13.
Koulourides, T.I., and Housch, T.: Demineralization and Mineralization Reactions of Enamel Surface, abstracted, IADR Program and Abstracts of Papers No. 451, 1970.
14.
Koulourides, T.I.: Personal communication.
15.
Bowen, W.H. : The Monitoring of Acid Production in Dental Plaque in Monkeys, Br Dent J126: 506-508, 1969.
16.
Cole, M.F., and Bowen, W.: The Effect of Calcium β Glycerophosphate on Phosphatase Activity in Plaque from Monkeys (Macaca fascicularis), Arch Oral Biol19: 335-337, 1974.
17.
Grenby, T.H. , and Bull, J.M.: Protection Against Dental Caries in Rats by Glycerophosphates or Calcium Salts or Mixtures of Both, Arch Oral Biol20: 717-724, 1975.
18.
Brook, A.H. ; Gawthorpe, J.; and Winter, G.B.: Calcium Glycerophosphate and Dental Plaque , Caries Res9: 156-162, 1975.
