Female newborns of cortisone-injected CD, strain of mice were mated to siblings, were then injected during pregnancy with 5 mg of cortisone on either the 11 th or the 12th day of gestation, and were killed one day after delivery. The incidence of induced cleft palate was as high as the incidence of cortisone-induced cleft palate previously reported for this strain.
Get full access to this article
View all access options for this article.
References
1.
Fraser, F.C. , and Fainstat, T.D.: Production of Congenital Defects in Offspring of Pregnant Mice Treated with Cortisone, Pediatr8: 527-533, 1951.
2.
Kalter, H.: Interplay of Intrinsic and Extrinsic Factors, in Wilson, J.G., and Warkany, J. (eds) : Teratology, Principles and Techniques, Chicago : The University of Chicago Press, 1965, pp 57-80.
3.
Gebhart, D.O.E. , and Schade, G.J.: Is There an Optimal Stage for the Induction of Cleft Palate in the Mouse? Cleft Palate J6: 373-380, 1969.
4.
Loevy, H.: Genetic Influences on Induced Cleft Palate in Different Strains of Mice, Anat Rec145: 117-122, 1963.
5.
Pinsky, L., and Di George, A.M.: Cleft Palate in the Mouse: A Teratogenic Index of Glucocorticoid Potency, Science147: 402-403, 1965.
6.
Loevy, H.: Lack of Difference in Sex Ratio of Mice with Cortisone-Induced Cleft Palate , J Dent Res52: 1016-1020, 1972 .
7.
Russell, W.L.: The Incidence of Sterility and Partial Sterility in the Descendents of X Irradiated Mice, Genetics35: 689-690, 1950.
8.
Russell, L.B., and Wickham, L.: The Incidence of Disturbed Fertility Among Male Mice Conceived at Various Intervals After Irradiation of the Mother, Genetics42: 392-393, 1957.
9.
Butcher, R.E.; Scott, W.J. ; Kazmaier, K.; and Ritter, E.J.: Postnatal Effects in Rats of Prenatal Treatment with Hydroxyurea, Teratology7: 161-166, 1973.
10.
Butcher, R.E. ; Vorhees, C.V.; and Kimmel, C.A.: Learning Impairment from Maternal Salicylate Treatment in Rats, Nature: [New Biol]236:211-212, 1972.
11.
Butcher, R.E. ; Brunner, R.L.; Roth, T.; and Kimmel, C.A.: A Learning Impairment Associated with Maternal Hypervitaminosis A in Rats, Life Science (Part I)11 : 141-145, 1972.
12.
Vorhees, C.V. : Some Behavioral Effects of Maternal Hypervitaminosis A in Rats, Teratology10: 269-274, 1974.
13.
Glaubach, S. ; Antopol, W.; and Graff, S.: Excessive Doses of Cortisone in Pregnant Mice: Effect on Development and Survival of the Fetus and Newborn and on the Maternal Breast Tissue, Bull NY Acad Med27: 398, 1951.
14.
Watney, M.J. , and Miller, J.R.: Prevention of a Genetically Determined Congenital Eye Anomaly in the Mouse by the Administration of Cortisine During Pregnancy, Nature (Lond) 202: 1029-1031, 1964.
15.
Dawson, A.B. : A Note on the Staining of the Skeleton of Cleared Specimens with Alizarin Red, Stain Tech1: 123-124, 1926.
