When convulsive doses of lidocaine hydrochloride were administered to mice that were killed seven minutes postinjection time, a depletion of central serotonin and dopamine was recorded. Serotonin depletion was 19% in the myelencephalon plus the met-encephalon and 21% in the mesencephalon plus the diencephalon. Dopamine depletion was 55% in the mesencephalon plus the diencephalon.
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References
1.
Azzaro, A.F.; Wenger, G.R.; Craig, C.R.; and Stitzel, R.E.: Reserpine-Induced Alterations in Brain Amines and Their Relationship to Changes in the Incidence of Minimal Electroshock Seizures in Mice, J Pharmacol Exp Ther180: 558-562, 1972.
2.
De LATorre, J.C., and Mullan, S.: A Possible Role for 5-Hydroxytryptamine in Drug Induced Seizures, J Pharm Pharmacol22: 853-859, 1970.
3.
Gray, W.D., and Rauh, C.E.: The Relationship Between Monoamines in Brain and the Anticonvulsant Action of Inhibitors of Carbonic Anhydrase, J Pharmacol Exp Ther177:206-218, 1971.
4.
Jones, B.J., and Roberts, D.J.: The Effects of Intracerebroventricularly Administered Noradnamine and Other Sympathominetic Amines upon Leptazol Convulsions in Mice, Br J Pharmacol34: 27-31, 1968.
5.
Prockop, D.J. ; Shore, P.A. ; and Brodie, B.B.: Anticonvulsant Properties of Monoamine Oxidase Inhibitors, Ann NY Acad Sci80: 643-655, 1959.
6.
Cooper, J.R.; Bloom, F.E.; and Roth, R.H.: The Biochemical Basis of Neuropharmacology, New York: Oxford University Press, 1970.
7.
Frank, G.B., and Sanders, H.D.: A Proposed Common Mechanism of Action for General and Local Anesthetics in the Central Nervous System, Br J Pharmac Chemother21: 1-9, 1963.
8.
Smudski, J.W.: Electroencephalographic and Behavioral Responses to Some Drugs Injected Directly into Specific Brain Areas of the Rabbit, PhD thesis, University of California, San Francisco.
9.
De Jong, R.H., and Walts, L.F.: Lidocaine Induced Psychomotor Seizures in Man, Acta Anesthesiol Scand [Suppl]23: 598-604, 1966.
10.
Wagman, I.H. ; DE Jong, R.H.; and Prince, D.A.: Effects of Lidocaine on Spontaneous Cortical and Subcortical Electrical Activity, Arch Neurol18: 277-290, 1968.
11.
Katz, J.: The Distribution of "C-Labeled Lidocaine Injected Intravenously in the Rat , Anesthesiology29: 249-253, 1968.
12.
Maickel, R.P. ; Cox, R.H., JR.; Saillant , J.; and Miller, F.P.: A Method for the Determination of Serotonin, and Norepinephrine in Discrete Areas of Rat Brain, Int J Neuropharmacol7: 275-281, 1968.
13.
Chang, C.C. : A Sensitive Method for Spectrophotofluorometric Assay of Catecholamines, Int J Neuropharmacol3: 643-649, 1964.
14.
Goldstein, A. : Biostatistics: An Introductory Text, New York: MacMillan Co., 1964, p 144.
15.
Glowinski, J., and Iverson, L.L.: Regional Studies of Catecholamines in Rat Brain: I, J Neurochem13: 655-659, 1966.
16.
Ciarlone, A.E. , and Smudski, J.W.: Influence of Lidocaine (LIDO) on Brain Monoamines in Mice, J Dent Res53(Special Issue): Abstract No. 195, 1974.
17.
Ungerstedt, U.: Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain, Acta Physiol Scand [Suppl]367: 1-47, 1971.
18.
Spector, S. ; Sjoerdsma, A.; and Udenfriend , S.: Blockade of Endogenous Norepinephrine Synthesis by Alpha-Methyltyrosine, an Inhibitor of Tyrosine Hydroxylase, J Pharmacol Exp Ther147: 86-95. 1965.
19.
Iverson, L.L. , and Glowinski, J.: Regional Studies of Catecholamines in the Rat Brain: II. Rate of Turnover of Catecholamines in Various Brain Regions , J Neurochem13: 671-682, 1966.
