Immunization Experiments Using the Rodent Caries Model

Jay P. ; Crowley M. ; Hadley F.P. ; and Bunting R.W. : Bacteriologic and Immunologic Studies on Dental Caries, JADA 20: 2130–2148, 1933.

Rosebury T. ; Foley G. ; Greenberg S. ; and Pollack F. : Studies of Lactobacilli in Relation to Caries in Rats: II. Attempt to Immunize Rats on Caries-Producing Diets Against Lactobacilli, J Dent Res 14: 231–232, 1934.

Canby C.P. , and Bernier J.L. : Bacteriologic and Immunologic Studies in Dental Caries: A Preliminary Report, JADA 29: 606–617, 1942.

Williams N.B. : Immunization of Human Beings with Oral Lactobacilli., J Dent Res 23: 403–411, 1944.

Fitzgerald R.J. , and Keyes P.H. : Attempted Immunization of Albino Hamsters Against Induced Dental Caries, abstracted, IADR Program and Abstracts of Papers, No. 40, 1962.

Keyes P.H. : The Infectious and Transmissible Nature of Experimental Dental Caries-Findings and Implications, Arch Oral Biol 1: 304–320, 1960.

Fitzgerald R.J. , and Keyes P.H. : Demonstration of the Etiologic Role of Streptococci in Experimental Caries in the Hamster., JADA 61: 9–19, 1960.

Tomasi T.B. Jr. ; Tan E.M. ; Solomon A. ; and Prendergast R.A. : Characteristics of an Immune System Common to Certain External Secretions, J Exp Med 121: 10–124, 1965.

Ogra P.L. , and Karzon D.T. : Distribution of Poliovirus Antibody in Serum, Nasopharynx and Alimentary Tract Following Segmental Immunization of Lower Alimentary Tract with Poliovaccine, J Immunol 102: 1423–1430, 1969.

Perkins J.C. ; Tucker D.N. ; Knopf H.L.S. ; Wenzel R.P. ; Kapikicen A.Z. ; and Chanock R.M. : Comparison of Protective Effect of Neutralizing Antibody in Serum and Nasal Secretions in Experimental Rhinovirus Type 13 Illness, Am J Epidemiol 90: 519–526, 1969.

Bellanti J.A. ; Buescher E.L. ; Brandt W.E. ; Dangerfield H.G. ; and Crozier D. : Characterization of Human Serum and Nasal Hemagglutinating Antibody to Francisella tularensis, J Immunol 98: 171–178, 1967.

Williams R.C. , and Gibbons R.J. : Inhibition of Bacterial Adherence by Secretory Immunoglobulin A: A Mechanism of Antigen Disposal, Science 177: 697–699, 1972.

Fubara E.S. and Freter R. : Protection Against Enteric Bacterial Infection by Secretory IgA Antibodies, J Immunol 111: 395–403, 1973.

Corbeil L.B. ; Schurig G.D. ; Duncan J.R. ; Corbeil R.R. ; and Winter A.J. : Immunoglobulin Classes and Biological Functions of Campylobacter (Vibrio) fetus Antibodies on Serum and Cervicovaginal Mucous, Infect Immun 10: 422–429, 1974.

Brandtzaeg P. ; Fjellanger I. ; and Geruldsen ST. : Human Secretory Immunoglobulins: 1. Saliva Secretions from Individuals with Normal or Low Levels of Serum Immunoglobulins Scand J Haematol (suppl) 12: 1–83, 1970.

Claman H.N. ; Merrill D.A. ; and Hartley T.F. : Salivary Immunoglobulins: Normal Adult Values and Dissociation Between Serum and Salivary Levels, J Allergy 40: 151–159, 1967.

Tourville D.R. ; Bienenstock J. ; and Tomasi T.B. Jr. ,: Natural Antibodies of Human Serum, Saliva and Urine Reactive with Escherichia coli, Proc Soc Exp Biol Med 128: 722–727, 1968.

Sirisinha S. : Reactions of Human Salivary Immunoglobulins with Indigenous Bacteria, Arch Oral Biol 15: 551–554, 1970.

Taubman M.A. , and Smith D.J. : Induction of Salivary IgA Antibody in Rats and Hamsters, J Dent Res 51 (special Issue): Abstract No. 276, 1973.

Bistany A.S. , and Tomasi T.B. Jr. : Serum Secretory Immunoglobulins of the Rat, Immunochemistry 7: 453–460, 1970.

McGhee J.R. ; Michalek S.M. ; Webb J. ; Navia J.M. ; Rahman A.F.R. ; and Legler D.W. : Effective Immunity to Dental Caries: Protection of Gnotobiotic Rats by Local Immunization with Streptococcus Mutans, J Immunol 114: 300–305, 1975.

Cambier J.C. ; Porter J.R. ; and Butler J.E. : Isolation, Characterization and Ultrastructural Localization of Rat Secretory Component and Secretory IgA., Fed Proc 33: 747, 1974.

Vaerman J.P. ; Heremans J.F. ; Bazin H. ; and Beckers A. : Identification and Some Properties of Rat Secretory Component., J Immunol 114: 265–269 1975.

Kobayshi K. ; Vaerman J.P. ; Bazin H. ; Lebacq-Verheyden A.M. ; and Heremans J.F. : Identification of J-chain in Polymeric Immunoglobulins from a Variety of Species by Cross Reaction with Rabbit Antisera to J-Chain, J Immunol 111: 1590–1594, 1973.

Genco R.J. , and Taubman M.A. : Secretory γ A Antibodies Induced by Local Immunization, Nature 221: 679–681, 1969.

Taubman M.A. , and Genco R.J. : Induction and Properties of Rabbit Secretory γ A Antibody Directed to Group A Streptococcal Carbohydrate, Immunochemistry 8: 1137–1155, 1971.

Taubman M.A. : Role of Immunization in Dental Disease, in Mergenhagen S. and Scherp H. (eds): Comparative Immunology of the Oral Cavity, Washington, DC: US Government Printing Office, 1973, pp 138–158.

Taubman M.A. , and Genco R.J. : The Immunoglobulins of Rabbit Saliva, abstracted, IADR Program and Abstracts of Papers, No. 162, 1969.

Taubman M.A. ; Emmings F.G. ; and Genco R.J. : Production of Antibodies and Immunoglobulins by Rabbit Salivary Glands, abstracted, IADR Program and Abstracts of Papers, No. 70, 1970.

Taubman M.A. , and Genco R.J. : Isolation of Rabbit Salivary γ A Antibody Directed to the Dinitrophenyl (DNP) Haptenic Group. abstracted, IADR Program and Abstracts of Papers, No. 262, 1971.

Taubman M.A. , and Smith D.J. : Effects of Local Immunization with Streptococcus mutans on Induction of Salivary Immunoglobulin A Antibody and Experimental Dental Caries in Rats, Infect Immun 9: 1079–1091, 1974.

Wagner M. : A Study of the Effects of Specific Immunization on Experimental Dental Caries, PhD thesis, Purdue University, 1966.

Wagner M. : Relationship of Specific Antibacterial Agglutinins in Saliva to Dental Caries in Gnotobiotic Rats, in Heneghan J.B. (ed): Germfree Research, New York: Academic Press Inc., 1973, pp 211–216.

Guggenheim B.H. ; Mühlemann H. ; Regolati B. ; and Schmid R. : The Effect of Immunization Against Streptococci of Glucosyl-Transferases on Plaque Formation and Dental Caries in Rats, in McHugh W.D. (ed): Dental Plaque, Dundee, Scotland: D. C. Thompson and Co., 1970, pp 287–296.

Hayashi J.A. ; Shklair I.L. ; and Bahn A.N. : Immunization with Dextransucrases and Glycosidic Hydrolases, J Dent Res 51: 436–442, 1972.

Tanzer J.M. ; Hageage G.J. ; and Larson R.H. : Variable Experiences in Immunization in Rats Against Streptococcus mutans-Associated Dental Caries, Arch Oral Biol 18: 1425–1439, 1973.

Olson G.B. , and Wostmann B.S. : Cellular and Humoral Immune Response of Germ-free Mice Stimulated with 7S HGG or Salmonella typhimurium, J Immunol 97: 275–286, 1966.

Skelly B.J. ; Celozzi E.M. ; and Boeninghaus H.G. : Neonatal Thymectomy in Gnotobiotic CDF Rats, Immunology 15: 497–501, 1968.

Larson R.H. , and Fitzgerald R.J. : Caries Development in Rats of Different Ages with Controlled Flora, Arch Oral Biol 9: 705–715, 1969.

McCabe M.M. , and Smith E.E. : Origin of the Cell Associated Dextransucrase of Streptococcus mutans, Infect Immun 1: 829–838, 1973.

Genco R.J. ; Evans R.T. ; and Taubman M.A. : Specificity of Antibodies to Streptococcus mutans: Significance in Inhibition of Adherence, Adv Exp Med Biol 43: 327–336, 1974.

Iacono V.J. , Taubman M.A. ; Smith D.J. ; and Levine M.J. : Isolation and Immunochemical Characterization of the Group-Specific Antigen of Streptococcus mutans 6715, Infect Immun 11: 117–128, 1975.

Mukasa H. , and Slade H. : Mechanisms of Adherence of S mutans to Smooth Surfaces. III. Purification and Properties of the Enzyme Complex Responsible for Adherence, Infect Immun 10: 1135–1145, 1974.

Fukui K. ; Fukui Y. ; and Moriyama T. : Purification and Properties of Dextransucrase and Invertase from Streptococus mutans, J Bacterial 118: 796–904, 1974.

Tomasi T. , and Grey H.M. : Structure and Function of IgA, Prog Allergy 16: 81–213, 1972.

Waldman R.H. , and Henney C.S. : Cell-Mediated Immunity and Antibody Response in the Respiratory Tract After Local and Systemic Immunization, J Exp Med 134: 482–494, 1971.

Sirisinha S. , and Charaputana C. : Antibody Responses in Serum, Secretions, and Urine of Man After Parenteral Administration of Vaccines, Infect Immun 2: 29–37, 1970.

Crabbé P.A. , Nash D.R. ; Bazin H. ; Eyssen H. ; and Heremans J.F. : Immunohistochemical Observations on Lymphoid Tissues from Conventional and Germ-Free Mice., Lab Invest 22: 448, 1970.

Brown W.R. ; Newcomb R.W. ; and Ishizaka K. : Proteolytic Degradation of Exocrine and Serum Immunoglobulins, J Clin Invest 49: 1374–1380, 1970.

Shuster J. : Pepsin Hydrolysis of IgA. De-lineation of Two Populations of Molecules, Immunochemistry 8: 405–411, 1971.

Steward M.W. : Resistance of Rabbit Secretory IgA to Proteolysis, Biochim Biophys Acta 236: 440–449, 1971.

Ghetie V. , and Mota G. : The Decrease of Human Colostral Immunoglobulin Resistance to Papain Action After Gradual Release of the Secretory Component., Immunochemistry 10: 839, 1973.

Lindh E. : Increased Resistance of Immunoglobulin A Dimers to Proteolytic Degradation After Binding of Secretory Component, J Immunol 114: 284–286, 1975.

Kennedy A.E. ; Shklair I.L. ; Hayashi J.A. ; and Bahn A.N. : Antibodies to Cariogenic Streptococci in Humans, Arch Oral Biol 13: 1275–1278, 1968.

Challacombe S.J. : Serum Antibodies in Subjects with Caries, J Dent Res 50: 654–655, 1971.

Challacombe S.J. ; Guggenheim B. ; and Lehner T. : Antibodies to an Extract of Streptococcus mutans, Containing Glucosyltransferase Activity, Related to Dental Caries in Man, Arch Oral Biol 18: 657–668, 1973.

Taubman M. : Immunoglobulins of Human Dental Plaque, Arch Oral Biol 19: 439–446, 1974.

Van Houte J. , Upeslacis V.N. ; Jordan H.V. ; Skobe Z. ; and Green D.B. : Role of Sucrose in the Colonization of Streptococcus mutans in Conventional Sprague-Dawley Rats, J Dent Res, unpublished manuscript.

Gibbons R.J. , and Banchart S. : Synthesis of Dextran by Cariogenic Bacteria and its Presence in Human Dental Plaque, Arch Oral Biol 12: 11–24, 1967.

Gibbons R.J. , and Nygaard M. : Synthesis of Insoluble Dextran and its Significance in the Formation of Gelatinous Deposits by Plaque-Forming Streptococci, Arch Oral Biol 13: 1249–1262, 1968.

Ikeda T. , and Sandham H.J. : Prevalence of Streptococcus mutans on Various Tooth Surface in Negro Children, Arch Oral Biol 16: 1237–1240, 1971.

König K.G. , and Guggenheim B. : Implantation of Antibiotic-Resistant Bacteria and the Production of Dental Caries in Rats, Adv Oral Biol 111: 217–252, 1968.

König K.G. ; Larson R.H. ; and Guggenheim B. : A Strain-Specific Eating Pattern as a Factor Limiting the Transmissibility of Caries Activity in Rats, Arch Oral Biol 14: 91–103, 1969.

Guggenheim B. : Enzymatic Hydrolysis and Structure of Water-Insoluble Glucan Produced by Glucosyltransferases from a Strain of Streptococcus mutans, Helv Odontol Acta 14: 89–108, 1970.

Wood J.M. , and Critchley P. : The Extracellular Polysaccharide Produced from Sucrose by a Cariogenic Streptococcus, Arch Oral Biol 11: 1039–1042, 1966.

McCabe R.M. ; Keyes P.H. ; and Howell A. : An In Vitro Method for Assessing the Plaque-Forming Ability of Oral Bacteria, Arch Oral Biol 12: 1653–1656, 1967.

Genco R.J. ; Discussion of Local Antibodies and Dental Disease, in Dayton D.H. Jr. , Small P.A. , Chanock R.M. , Kaufman H.E. , and Tomasi T.B. (eds): The Secretory Immunologic System, Washington, DC: US Government Printing Office, 1971, pp 254–255.

Mukasa H. , and Slade H.D. : Mechanisms of Adherence of S mutans to Smooth Surfaces: I. Roles of Insoluble Dextran-Levan Synthetase Enzymes and Cell Wall Polysac-charide Antigens in Plaque Formation, Infect Immun 8: 555–562, 1973.

Olson G.A. ; Bleiweis A.S. ; and Small P.A. : Adherence Inhibition of Streptococcus mutans: an Assay Reflecting a Possible Role of Antibody in Dental Caries Prophylaxis, Infect Immun 5: 419–427, 1972.

Genco R.J. , and Taubman M.A. : Biological Properties of Secretory IgA Antibodies, in Mergenhagen S. , and Scherp H. (eds): Comparative Immunology of the Oral Cavity, Washington, DC: US Government Printing Office, 1973, pp 25–37.

Mukasa H. , and Slade H.D. : Mechanism of Adherence of S mutans to Smooth Surfaces: II. Nature of the Binding Site and the Adsorption of Dextran-Levan Synthetase Enzymes on the Cell-Wall Surface of the Streptococcus, Infect Immun 9: 419–429, 1974.

Olson G.A. ; Guggenheim B. ; and Small P.A. : Antibody-Mediated Inhibition of Dextran/Sucrose-Induced Agglutination of Streptococcus mutans, Infect Immun 9: 273–278, 1974.

Gibbons R.J. : Presence of an Invertase-Like Enzyme and a Sucrose Permeation System in Strains of Streptococcus mutans, Caries Res 6: 122–131, 1972.

McCabe M.M. , and Smith E.E. : Invertase Activity in Streptococcus mutans and Streptococcus sanguis, Arch Oral Biol 18: 525–531, 1973.

Tanzer J.M. ; Brown A.T. ; McInerney M.F. : Identification, Preliminary Characterization, and Evidence for Regulation of Invertase in Streptococcus mutans, Infect Immun 9: 192–202, 1973.

Taubman M.A. , and Smith D.J. : Immunologic Control of Indigenous Flora Pathogenicity, in Rowe N.H. (ed): Dental Plaque, Interfaces; Ann Arbor: University of Michigan Press, 1974, pp 107–124.

Emmings F.G. , and Genco R.J. : The IgA Antibody-Forming Cell Response in the Rabbit Submandibular Gland Following Several Different Methods of Immunization, Adv Exp Med Biol 45: 467–471, 1974.

Emmings F.G. ; Evans R.T. ; and Genco R.J. : Induction of Salivary IgA Antibody to S mutans in Macaca iris, J Dent Res 53 (Special Issue) Abstract No. 184, 1974.