8-Hydroxyquinoline sulfate inhibited formation of artificial calculus in vitro and rat calculus in vivo. In rats, it prevented calculus formation when applied by swabbing or by intraoral instillation. In dogs, formation of dental plaque was inhibited by 33 to 98% in comparison to placebo. Also in dogs, 25 to 58% of established plaque accumulations were removed by 8-hydroxyquinoline sulfate whereas placebo removed 2 to 22%. No systemic or local toxic effects were observed.
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