The effect of dietary supplementation of glycine at a level of 4% on caries development and the lipid content of rat molar teeth was studied. The glycine supplementation caused a 65.7% reduction in caries development and a 15.1% reduction in lipid content. In a concurrent balance study, it was noted that the dietary glycine did not have any significant effect on the retention of either calcium or phosphorus by the rat's body. Changes in the fatty acid composition of the tooth and a reduction in growth rate were noted, however.
Get full access to this article
View all access options for this article.
References
1.
Drummond, K.N. , and Michael, A.F.: Specificity of the Inhibition of Tubular Phosphate Reabsorption by Certain Amino Acids, Nature (London) 201: 1333-1334, 1964 .
2.
Michael, A.F. ; Drummond, K.N.; Ulstrom , R.A.; and Good, R.A.: Blue Diaper Syndrome : Familial Hypercalcemia of Infancy Associated with Abnormal Tryptophan Metabolism, Am J Dis Child104: 510-512, 1962.
3.
Nizel, A.E., and Harris, R.S.: The Effects of Phosphates on Experimental Dental Caries: A Literature Review , J Dent Res43 : 1123-1136, 1964 .
4.
Harris, R.S. ; Das, S.K.; and Nizel, A.E.: Cariostatic Effects of Three Types of Phosphates when Fed Singly or in Combinations in the Diets of Rats, J Den Res44: 549-553, 1965.
5.
Buttner, W., and Muhler, J.C.: Effect of Varying Levels of DL-Tryptophan in Diet on Dental Caries in Rats , Proc Soc Exp Biol Med95: 309-311, 1957.
6.
McChure, F.J. , and Folk, J.E.: Lysine and Cariogenicity of Two Experimental Rat Diets, Science122: 557-558, 1955.
7.
Bernick, S., and Bavetta, L.A.: Histochemical and Electron Microscopy Study of Dentine in Tryptophan Deficient Rats, J Dent Res36: 142-149, 1957.
8.
Ponlot, R.: Le Radiocalcium dans L'Etude des Os, Bruxelles : Editions Arsica, 1960, p 54.
9.
Irving, J.T. , and Wuthier, R.E.: Further Observations on the Sudan Black Stain for Calcification, Arch Oral Biol5: 323-324, 1961.
10.
Dirksen, T.R. : Lipid Components of Sound and Carious Dentin , J Dent Res43: 128-132, 1963.
11.
Das, S.K.: Factors Affecting the Fatty Acid Composition of Teeth, ScD thesis , Massachusetts Institute of Technology, Cambridge, Mass , 1966.
12.
Allred, H.: Histochemical Observations on the Lipids of Carious Human Dentine , Nature (London) 210: 748, 1966 .
13.
Das, S.K. , and Harris, R.S.: Effects of Dietary Restriction on the Composition of Lipids in Rat Teeth, Arch Oral Biol, 20: 131-135, 1970.
14.
Alam, S.Q., and Harris, R.S.: Effects of Nutrition on the Composition of Tooth Lipids and Fatty Acids in Rats: I. The Effects of Dietary Carbohydrates on Fatty Acid Composition of Rat Teeth, J Dent Res51: 1474-1477, 1972 .
15.
Prout, R.E.S. , and Atkin, E.R.: Effect of Diet Deficient in Essential Fatty Acid on Fatty Acid Composition of Enamel and Dentine of the Rat, Arch Oral Biol18: 583-590, 1973.
16.
Hoppert, C.A. ; Webber, P.A.; and Caniff, T.L.: Production of Dental Caries in Rats Fed Adequate Diet, J Dent Res12: 161-173, 1932.
17.
Johansen, E. , and Keyes, P.H.: Production and Evaluation of Experimental Animal Caries: A Review, in SoGNNAEs, R.F. (ed) : Advances in Experimental Caries Research, Washington, DC: American Association for the Advancement of Science, 1955 , pp 1-46.
18.
Horwitz, W. (ed) : Official Methods of Analysis, 9th ed, Association of Official Agricultural Chemists, 1960, pp 643-644.
19.
Piez, K.A., and Morris, L.: A Modified Procedure for the Automatic Analysis of Amino Acids, Anal Biochem1 : 187, 1960.
20.
Salomon, K. ; Gabrio, B.W.; and Smith, G.F.: A Precision Method for the Quantitative Determination of Calcium in Blood Plasma, Arch Biochem11:433-443, 1946.
21.
Chen, P.S.; Toribara, T.Y.; and Warner, H.: Microdetermination of Phosphorus, Anal Chem28: 1756-1758, 1956.
22.
Das, S.K. , and Harris, R.S.: Fatty Acids in Tooth Lipids of 16 Animal Species, J Dent Res49: 119-125, 1970.
23.
Steel, R.G.D. , and Torre, J.H.: Principles and Procedures in Statistics , New York: Mc-Graw-Hill Book Co. , 1960.
24.
Veis, A., and Schlueter, R.J.: Presence of Phosphate-Mediated Crosslinkages in Hard Tissue Collagens , Nature (London) 197: 1204, 1963 .
25.
Lehmann, H., and Pollak, L.: The Influence of Amino Acid on Transfer of Phosphate in Muscle Extract and on the Solubility of Magnesium and Calcium Salts, abstracted, Proceedings of the Physiological Society, Feb 14, 1942, p 17.
