The abilities of five, long-chain aliphatic monamines to inhibit the deposition of Plaque formed by Streptococcus mutans on stainless-steel wires were determined. The compounds along with their relative inhibitory potencies that were studied are N-methyltetradecylamine, hexadecylamine, dodecylamine, N-ethyldodecylamine, and octylamine. Activities are compared with critical micelle concentrations, partition coefficients, and quantum mechanical charges on the amine nitrogens.
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References
1.
Burnett, G.W. : The Microbiology of Dental Infections, Dent Clin North Am14: 681-695, 1970.
2.
Katz, S. ; Beck, C.W.; and Muhler, J.C.: Crystallographic Evaluation of Enamel from Carious and Noncarious Teeth, J Dent Res48: 1280-1283, 1969 .
3.
Jenkins, G.N. : The Mode of Formation of Dental Plaque, Caries Res2: 130-138, 1968.
4.
Guggenheim, B., and Schroeder, H.E.: Biochemical and Morphological Aspects of Extracellular Polysaccharides Produced by Cariogenic Streptococci , Helv Odontol Acta11: 131-152, 1967.
5.
Gibbons, R.J. : Formation and Significance of Bacterial Polysaccharides in Caries Etiology, Caries Res2: 164-171, 1968.
6.
Jordan, H.V. , and Keyes, P.H.: In Vitro Methods for the Study of Plaque Formation and Carious Lesions, Arch Oral Biol11: 793-801, 1966.
7.
Shern, R.; Swing, K.W.; and Crawford, J.J.: Prevention of Plaque Formation by Organic Fluorides, J Oral Med25: 93-97, 1970.
8.
Herman, H., and Mühlemann, H.R.: Inhibition of Salivary Respiration and Glycolysis by an Organic Fluoride , Helv Odontol Acta2: 28-33, 1958.
9.
Mchlemann, H.R. ; Schait, A.; and König, K.G.: Fluoride Uptake of Enamel and Animal Caries Inhibition of Sodium Fluoride and Aminofluroides at Low Fluoride Concentrations , Helv Odontol Acta12: 61-66, 1968.
10.
Mühlemann, H.R.; Schmid, H.; and König, K.G.: Enamel Solubility Reduction Studies with Inorganic and Organic Fluorides, Helv Odontol Acta1 : 23-32, 1957.
11.
König, K.G. ; Marthaler, T.M.; and Mühlemann , H.R.: Interrelation between Enamel Solubility Reduction and Caries Inhibition, Helv Odontol Acta2: 34-39, 1958.
12.
Mühlemann, H.R., and Wolgensinger , F.: In Vivo Reduction of Enamel Solubility in Children Using an Organic Fluoride Dentifrice, Helv Odontol Acta3: 35-38, 1959.
13.
Marthaler, T.M.: Toxicity Studies with Sodium Fluoride and Amine Fluorides, Helv Odontol Acta4: 33-39, 1960.
14.
Malcolm, J. ; Deaker, E.M.; and Bell, M.E.: Toxicity Trials with, Cetylamine, J Dent Res30: 214-217, 1951.
15.
Marthaler, T.M.: Toxic Effects in Diet of Sodium Fluoride and Amine Fluorides, Helv Odontol Acta6: 15-20, 1962.
16.
Marthaler, T.M.: The Caries-Inhibiting Effects of Amine Fluoride Dentifrices in Children During Three Years of Unsupervised Use, Br Dent J119: 153-163, 1965.
17.
Marthaler, T.M.: Caries Inhibition after Seven Years of Unsupervised Use of an Amine Fluoride Dentifrice, Br Dent J124: 510-515, 1968.
18.
Marthaler, T.M.; König, K.G.; and Mühlemann , H.R.: The Effect of a Fluoride Gel Used for Supervised Toothbrushing 15 or 30 Times per Year , Helv Odontol Acta14: 67-77, 1970.
19.
Adamson, A.W. : Physical Chemistry of Surfaces, 2nd ed, New York: Interscience Publishers, 1967, pp 24 and 491.
20.
Iwasa, J.; Fujita, T.; and Hansch, C.: Substituent Constants for Aliphatic Functions Obtained from Partition Coefficients , J Med Chem8: 150-153, 1965.
21.
Hansch, C., and Lien, E.J.: Structure-Activity Relationships in Antifungal Agents: A Survey, J Med Chem14: 653-670, 1971.
22.
Del Re G.: Theoretical Procedures for the Study of Biochemical Systems, in Pullman, B. (ed) : Electronic Aspects of Biochemistry , New York: Academic Press, Inc. , 1964 , pp 221-235.