Weanling rats were administered 20, 380, and 20,000 ppm F as clear precipitatefree SnF2 solutions. Equivalent ppm F as NaF solution was similarly administered for comparison. The rats were autopsied at the end of the study for histological examination of kidney, liver, and incisors. The pathognomonic manifestations were correlated with the plasma F levels.
Get full access to this article
View all access options for this article.
References
1.
Hein, J.W.; Bonner, J.F.; Brudevold, F.; Smith, F.A.; and Hodge, C.A.: Distribution in the Soft Tissue of the Rat of Radioactive Fluoride Administered as Sodium Fluoride, Nature (Lond) 178:1295, 1956.
2.
Zipkin, I., and Likins, R.C.: Absorption of Various Fluoride Compounds from the Gastrointestinal Tract of the Rat, Am J Physiol191: 549, 1957.
3.
Weddle, D.A. , and Muhler, J.C.: 1. Comparison Between Sodium Fluoride, Sodium Silicofluoride, and Stannous Fluoride, J Dent Res36: 386, 1957.
4.
Segreto, V.A. ; Yeary, R.A.; Brooks, R.; anc Harris, N.O.: Toxicity Study of Stannous Fluoride in Swiss Strain Mice, J Dent Res40: 623, 1961.
5.
Lim, J.K. , and Hsieh, J.B.: Solubility of Surface Enamel Treated with PrecipitateFree Aqueous Solutions of Stannous Fluoride, J Dent Res50: 531, 1971.
6.
Brudevold, F. ; Bakhos, Y.; and Gron, P.: Fluoride in Human Saliva After Ingestion of Aluminum Chloride and Sodium Fluoride or Sodium Monofluorophosphate, Arch Oral Biol18: 699, 1973.
7.
Lim, J.K. : Precipitate-Free, Dilute Aqueous Solutions of Stannous Fluoride for Topical ApplicationI. Simple and Mixed Mediums, J Dent Res49: 760, 1970.
8.
Sorg, D.A., and Buckner, B.: A Simple Method of Obtaining Venous Blood from Small Laboratory Animals, Proc Soc Exp Biol Med115: 1131, 1964.
9.
Fry, B.W. , and Taves, D.R.: Serum Fluoride Analysis with the Fluoride Electrode, J Lab Clin Med75: 1020, 1970.
10.
Ruzicka, J.A. ; Klas, L.; and Rokytova, K.: Influence of Water Intake on the Degree of Incisor Fluorosis and on the Incorporation of Fluoride into Bones and Incisor Teeth of Mice, Caries Res7: 166, 1973.
11.
Kruger, B.J. : Histological Effects of Fluoride and Molybdenum on Developing Dental Tissues, Aus Dent J12: 54, 1967.