Intra-arterial infusion of carbamyl phosphate or of carbamyl-DL-aspartic acid into rats on a cariogenic diet greatly stimulated the movement of fluid through the odontoblastic processes. The infusion of sodium cyanate also stimulated fluid movement. Guanidine HCl and L-asparagine were active at higher concentrations. Purifying the urea on a mixed-bed ion exchange resin virtually removed its stimulatory effect on dentinal fluid movement. The action of urea is apparently attributable to contamination with sodium cyanate.
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References
1.
Steinman, R.R. , and Hardinge, M.G.: The Effect of Pyridoxine and Injected Carbohydrate on Incidence of Caries, Dentinal Circulation Related to Diet, J Dent Res37 : 874-879, 1958.
2.
Steinman, R.R. : The Physiological Basis for Caries Susceptibility and Resistance, J S Calif State Dent Assoc29: 221-224, 1961.
3.
Steinman, R.R. : The Movement of Acriflavine Hydrochloride through Molars of Rats on a Cariogenic and Non-cariogenic Diet, J S Calif State Dent Assoc35: 151-157, 1967.
4.
Steinman, R.R. : Pharmacologic Control of Dentinal Fluid Movement and Dental Caries in Rats, J Dent Res47: 720-724, 1968.
5.
Leonora, J., and Steinman, R.R.: Evidence Suggesting the Existence of a Hypothalamic-Parotid Gland Endocrine Axis, Endocrinology83: 807-815, 1968.
6.
Sanchez, A.; Steinman, R.R.; and Leonora, J.: Effect of Diet on Dentinal Fluid Movement in Germfree and Nongermfree Rats , Am J Clin Nutr23: 686-690, 1970.
7.
Steinman, R.R. , and Leonora, J.: Relationship of Fluid Transport through the Dentin to the Incidence of Dental Caries, J Dent Res50: 1536-1543, 1971.
8.
Steinman, R.R. ; Hewes, C.G.; and Woods, R.W.: Histochemical Analysis of Lesions in Incipient Dental Caries, J Dent Res38 : 592-605, 1959.
